D9286
Paraoxon-ethyl
≥90%, oil
동의어(들):
O,O-Diethyl O-(4-nitrophenyl) phosphate, Diethyl p-nitrophenyl phosphate, Paraoxon, Paraoxon-ethyl
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
O2NC6H4OP(O)(OC2H5)2
CAS 번호:
Molecular Weight:
275.20
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
206-221-0
Beilstein/REAXYS Number:
1915526
MDL number:
InChI key
WYMSBXTXOHUIGT-UHFFFAOYSA-N
InChI
1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
SMILES string
CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
assay
≥90%
form
oil
color
yellow
refractive index
n20/D 1.51 (lit.)
density
1.274 g/mL at 25 °C (lit.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... PON1(5444)
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Application
Paraoxon-ethyl has been used as a substrate in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein L3 (HDL3) to HDL2 in vivo.
Biochem/physiol Actions
Potent irreversible acetylcholinesterase inhibitor
Physical form
Oily liquid
Disclaimer
air sensitive: handle under argon
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Elena Grao-Cruces et al.
Biomedicines, 9(11) (2021-11-28)
High-density lipoproteins (HDLs) play an important role in reverse cholesterol transport and present antioxidant properties, among others. In the central nervous system (CNS), there are HDLs, where these lipoproteins could influence brain health. Owing to the new evidence of HDL
Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib
Johns DG, et al.
European Journal of Pharmacology, 762, 256-262 (2015)
Nicholas J Woudberg et al.
Lipids in health and disease, 17(1), 232-232 (2018-10-12)
Obesity is associated with a change in high-density lipoprotein (HDL) function and subclass. Exercise training reduces cardiovascular risk in obese patients. We aimed to explore the effect of an exercise training stimulus on HDL functionality and subclass in obese women.
Altered lipoproteins in patients with systemic lupus erythematosus are associated with augmented oxidative stress: a potential role in atherosclerosis
Park JK, et al.
Arthritis Research & Therapy, 18(1), 306-306 (2016)
Association between ethnicity and obesity with high-density lipoprotein (HDL) function and subclass distribution
Woudberg NJ, et al.
Lipids in Health and Disease, 15(1), 92-92 (2016)
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