E1631
β-Estradiol 17-valerate
≥98% (HPLC), powder
동의어(들):
1,3,5(10)-Estratriene-3,17β-diol 17-pentanote
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C23H32O3
CAS 번호:
Molecular Weight:
356.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
213-559-2
MDL number:
Beilstein/REAXYS Number:
2480357
제품 이름
β-Estradiol 17-valerate, ≥98%
InChI key
RSEPBGGWRJCQGY-UHFFFAOYSA-N
InChI
1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3
SMILES string
CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C
biological source
synthetic
assay
≥98%
form
powder
technique(s)
ELISA: suitable
solubility
acetone: 25 mg/mL, hazy, colorless
shipped in
ambient
storage temp.
room temp
Quality Level
관련 카테고리
General description
β-Estradiol 17-valerate is a synthetic estrogen.
Application
β-Estradiol 17-valerate has been used:
- in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions
- to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice
- to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model
Biochem/physiol Actions
Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms. β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models. It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Elizabeth Micks et al.
Women's health (London, England), 7(5), 513-524 (2011-09-02)
Estradiol valerate and dienogest have been combined to create a novel four-phasic oral contraceptive pill effective for both pregnancy prevention and treatment of heavy menstrual bleeding. This formulation represents the only oral contraceptive pill available in the USA containing an
L J Seal et al.
The Journal of clinical endocrinology and metabolism, 97(12), 4422-4428 (2012-10-12)
Breast development in transwomen is an important issue, affecting general psychological functioning. Current hormonal therapies are imperfect, with 60% of patients requesting mammoplasty. Interventions included the following: 1) comparing the effects on transwomen's requests for mammoplasty of estrogen valerate, ethinylestradiol
Bingli Lei et al.
Aquatic toxicology (Amsterdam, Netherlands), 134-135, 128-134 (2013-04-24)
β-estradiol 17-valerate (EV) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy drugs and is detected in natural waters. Although EV is known as an estrogenic chemical, there is still a lack of
Marika Christina Möller et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 29(2), 173-176 (2012-10-26)
Both estrogen and testosterone insufficiency has been associated with reduced psychological well-being including fatigue. However, hormonal replacement studies on fatigue are rare. Therefore, we wanted to study the effect of testosterone and estrogen replacement therapy on cognitive fatigue and the
Gonzalo Cruz et al.
Fertility and sterility, 98(5), 1283-1290 (2012-08-03)
To investigate the developmental window in which E(2) exposure produces irreversible changes in ovarian function resulting in polycystic ovary. Basic experimental study. University animal laboratory. Thirty Sprague-Dawley rats were administered a single E(2) valerate dose (10 mg/kg of weight) at
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