F0881

Fusidic acid sodium salt

Name: Fusidic acid sodium salt
Brand: SIGMA

≥98% (TLC), Bacterial protein synthesis inhibitor

동의어(들):

Fucidin

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

Linear Formula:

C₃₁H₄₇O₆Na

CAS 번호:

751-94-0

Molecular Weight:

538.69

NACRES:

NA.77

PubChem Substance ID:

24278430

UNSPSC Code:

12352106

EC Number:

212-030-3

MDL number:

MFCD09054714

Assay:

≥98% (TLC)

Quality level:

200

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제품 이름

Fusidic acid sodium salt, ≥98% (TLC)

InChI

1S/C31H48O6.Na/c1-17(2)9-8-10-20(28(35)36)26-22-15-24(34)27-29(5)13-12-23(33)18(3)21(29)11-14-30(27,6)31(22,7)16-25(26)37-19(4)32;/h9,18,21-25,27,33-34H,8,10-16H2,1-7H3,(H,35,36);/q;+1/p-1/b26-20-;/t18-,21-,22-,23+,24+,25-,27-,29-,30-,31-;/m0./s1

InChI key

HJHVQCXHVMGZNC-JCJNLNMISA-M

SMILES string

[Na+].C[C@@H]1[C@H](O)CC[C@@]2(C)C1CC[C@@]3(C)C2[C@H](O)CC4\C([C@H](C[C@]34C)OC(C)=O)=C(/CC\C=C(\C)C)C([O-])=O

assay

≥98% (TLC)

solubility

H₂O: soluble

antibiotic activity spectrum

neoplastics

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

General description

Fusidic acid is an antibiotic substance, resembling the structure of a steroid. It belongs to the class of fusidanes.

Application

Fusidic acid sodium salt has been used to study the effects of three-drug combinations on the growth rate of a bacterium, wild-type Escherichia coli. It is also used to study the in vitro susceptibility of dog-derived European methicillin-resistant Staphylococcus pseudintermedius and Staphylococcus aureus strains and their methicillin-susceptible counterparts.

Biochem/physiol Actions

Fusidic acid possesses antimicrobial action against skin pathogens. It is highly specific to Staphylococcus aureus. It is therefore used for treating infected traumatic wounds, folliculitis, furunculosis, impetigo, erythrasma and abscesses.

Suppresses nitric oxide lysis of pancreatic islet cells. Inhibits protein synthesis in prokaryotes by inhibiting the ribosome-dependent activity of G factor and translocation of peptidyl-tRNA.

Suppresses nitric oxide lysis of pancreatic islet cells; inhibits protein synthesis in prokaryotes.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Hazard Classifications

Acute Tox. 4 Oral

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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문서 라이브러리 방문

Enhanced identification of synergistic and antagonistic emergent interactions among three or more drugs

<BIG>Tekin E, et al.</BIG>

Journal of the Royal Society, Interface / the Royal Society, 20160332-20160332 (2016)

Fusidic acid in dermatology

British Journal of Dermatology, 37-40 (1998)

Susceptibility in vitro of canine methicillin-resistant and-susceptible staphylococcal isolates to fusidic acid, chlorhexidine and miconazole: opportunities for topical therapy of canine superficial pyoderma

<BIG>Clark SM, et al. </BIG>

The Journal of Antimicrobial Chemotherapy, 2048-2052 (2015)

Population pharmacokinetics of fusidic acid: rationale for front-loaded dosing regimens due to autoinhibition of clearance.

Jürgen B Bulitta et al.

Antimicrobial agents and chemotherapy, 57(1), 498-507 (2012-11-14)

The objectives of this analysis were to develop a population pharmacokinetic (PK) model to describe the absorption and disposition of fusidic acid after single and multiple doses and to determine the effect of food on the rate and extent of

DNA microarray profiling of a diverse collection of nosocomial methicillin-resistant staphylococcus aureus isolates assigns the majority to the correct sequence type and staphylococcal cassette chromosome mec (SCCmec) type and results in the subsequent identification and characterization of novel SCCmec-SCCM1 composite islands.

Anna C Shore et al.

Antimicrobial agents and chemotherapy, 56(10), 5340-5355 (2012-08-08)

One hundred seventy-five isolates representative of methicillin-resistant Staphylococcus aureus (MRSA) clones that predominated in Irish hospitals between 1971 and 2004 and that previously underwent multilocus sequence typing (MLST) and staphylococcal cassette chromosome mec (SCCmec) typing were characterized by spa typing

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Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Fusidic acid sodium salt

≥98% (TLC), Bacterial protein synthesis inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI

InChI key

SMILES string

assay

solubility

antibiotic activity spectrum

mode of action

storage temp.

Quality Level

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

Hazard Classifications

pictograms

signalword

hcodes

pcodes

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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