F3422
Flt-3/Flk-2 ligand human
recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE and HPLC)
동의어(들):
FL
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
≤1.0 ng/mL
mol wt
17.6 kDa
packaging
pkg of 5 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... FLT3(2322)
General description
Mouse and human Flt-3 ligand share ~72% homology and both demonstrate cross-species activity.
Biochem/physiol Actions
Flt-3/Flk-2 Ligand (FL, or Flt-3L) is a transmembrane glycoprotein that binds and activates the Flt-3 receptor. Expression of Flt-3 is primarily restricted among hematopoietic cells to the most primitive progenitor cells.
Physical form
Lyophilized, 0.2 μm sterile filtered, with with 0.5x PBS.
Analysis Note
The biological activity is measured by its ability to stimulate the proliferation of human AML5 cells.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Lyman, S., et al. et al.
The Cytokine Handbook, 727-727 (1998)
R Namikawa et al.
Stem cells (Dayton, Ohio), 14(4), 388-395 (1996-07-01)
The biological activities of the ligand for the Flk2/Flt3 receptor tyrosine kinase (FL) on human hematopoietic cells are reviewed. In in vitro studies, FL shows relatively few effects by itself on the proliferation and differentiation of hematopoietic cells, but exhibits
S D Lyman et al.
Oncogene, 8(4), 815-822 (1993-04-01)
We have developed rabbit polyclonal antibodies to the C-terminus of the flt3-encoded protein, which is a member of the receptor tyrosine kinase family. Immunoprecipitation using this antiserum brings down two protein bands, a major band of 143 kDa and a
H G Drexler et al.
Leukemia & lymphoma, 33(1-2), 83-91 (1999-04-08)
FLT3 ligand (FL) acting through its tyrosine kinase receptor FLT3 has pleiotropic and potent effects on hematopoietic cells. The well-described involvement of this ligand-receptor pair in physiological hematopoiesis raised the question whether FL and FLT3 also play a role in
O Rosnet et al.
Oncogene, 6(9), 1641-1650 (1991-09-01)
Receptor-type tyrosine kinases presenting an extracellular region with five immunoglobulin-like domains, and strongly related by sequence similarities in the intracellular region, constitute a family of receptors involved in development and function of various cell lineages. We have isolated and characterized
문서
Read article on hematopoietic cytokines and hematopoiesis
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