F3680

10058-F4

Name: 10058-F4
Brand: SIGMA

≥98% (HPLC), c-Myc inhibitor, solid

동의어(들):

5-[(4-Ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₁NOS₂

CAS 번호:

403811-55-2

Molecular Weight:

249.35

UNSPSC Code:

12352200

PubChem Substance ID:

329799701

NACRES:

NA.77

MDL number:

MFCD00758517

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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제품 이름

10058-F4, ≥98% (HPLC), solid

SMILES string

CCc1ccc(cc1)\C=C2\SC(=S)NC2=O

InChI key

SVXDHPADAXBMFB-JXMROGBWSA-N

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

assay

≥98% (HPLC)

form

solid

color

yellow

solubility

DMSO: >10 mg/mL, H₂O: <2 mg/mL

storage temp.

2-8°C

Quality Level

100

Application

10058-F4 has been used:

as c-Myc inhibitor to treat stromal cells
as c-Myc inhibitor to determine the effect of c-Myc inhibition on cardiac progenitor cells (CPC) growth
as c-Myc inhibitor to culture T cells
to treat C4-2 cells to examine the activity of MST1 promoter luciferase reporter construct

Biochem/physiol Actions

10058-F4 is a c-Myc inhibitor that induces cell-cycle arrest and apoptosis. 10058-F4 is a cell-permeable thiazolidinone that specificallly inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression. 10058-F4 inhibits tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).

10058-F4 is a c-Myc inhibitor.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

GHS07

signalword

Warning

hcodes

H317,H319

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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문서 라이브러리 방문

Overexpression of MYC and EZH2 cooperates to epigenetically silence MST1 expression

Kuser-Abali G, et al.

Epigenetics, 9(4), 634-643 (2014)

Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum.

Camilla U Persson et al.

Scientific reports, 7(1), 10274-10274 (2017-09-02)

Cultured cancer cells serve as important models for preclinical testing of anti-cancer compounds. However, the optimal conditions for retaining original tumor features during in vitro culturing of cancer cells have not been investigated in detail. Here we show that serum-free

cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response

Madapura HS, et al.

Cell Cycle, 15(9), 1267-1275 (2016)

Hypoxic Stress Decreases c-Myc Protein Stability in Cardiac Progenitor Cells Inducing Quiescence and Compromising Their Proliferative and Vasculogenic Potential

Bellio MA, et al.

Scientific reports, 7(1), 9702-9702 (2017)

DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling.

Kazuya Ishiguro et al.

Haematologica, 104(1), 155-165 (2018-09-02)

Epigenetic alterations play an important role in the pathogenesis in multiple myeloma, but their biological and clinical relevance is not fully understood. Here, we show that DOT1L, which catalyzes methylation of histone H3 lysine 79, is required for myeloma cell

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문서

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

10058-F4

≥98% (HPLC), c-Myc inhibitor, solid

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI key

InChI

assay

form

color

solubility

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

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