F4381

Furosemide

Name: Furosemide
Brand: SIGMA

≥98% (HPLC), powder, NKCC symporter inhibitor

동의어(들):

4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₂H₁₁ClN₂O₅S

CAS 번호:

54-31-9

Molecular Weight:

330.74

NACRES:

NA.77

PubChem Substance ID:

24277714

UNSPSC Code:

12352200

EC Number:

200-203-6

MDL number:

MFCD00010549

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

주요 문서

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제품 이름

Furosemide,

InChI key

ZZUFCTLCJUWOSV-UHFFFAOYSA-N

InChI

1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)

SMILES string

NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

mp

220 °C (dec.) (lit.)

solubility

acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow

originator

Sanofi Aventis

storage temp.

room temp

Quality Level

200

Gene Information

human ... ALB(213), CYP1A2(1544), SLC12A1(6557)

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Application

Furosemide has been used:

to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Biochem/physiol Actions

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Furosemide is a an ototoxic high-ceiling diuretic.

pictograms

GHS08,GHS07

signalword

Danger

hcodes

H302,H360FD

pcodes

P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405

Hazard Classifications

Acute Tox. 4 Oral - Repr. 1B

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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문서 라이브러리 방문

Diuretics

Side Effects of Drugs Annual, 28, 233-243 (2005)

Topiramate is more effective than acetazolamide at lowering intracranial pressure

Scotton W J, et al.

Cephalalgia, 0333102418776455-0333102418776455 (2018)

Comparison of arterial pressure and plasma AngII responses to three methods of subcutaneous AngII administration

Kuroki M T, et al.

American Journal of Physiology. Heart and Circulatory Physiology (2014)

Development of an ototoxicity model in the adult CBA/CaJ mouse and determination of a golden window of corticosteroid intervention for otoprotection

Fernandes V T and Lin V YW

Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'Oto-rhino-laryngologie et de Chirurgie Cervico-Faciale, 43(1), 12-12 (2014)

Furosemide

Saunders Handbook of Veterinary Drugs - E-Book (2016)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for ADME/Tox

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

biological source

assay

form

mp

solubility

originator

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

General description

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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