F9427

Fexofenadine hydrochloride

Name: Fexofenadine hydrochloride
Brand: SIGMA

>98% (HPLC), H1 histamine receptor antagonist, powder

동의어(들):

Fexofenidine hydrochloride, MDL 16455 hydrochloride, Terfenidine carboxylate hydrochloride

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₃₂H₃₉NO₄ · HCl

CAS 번호:

153439-40-8

Molecular Weight:

538.12

UNSPSC Code:

12352200

PubChem Substance ID:

24278447

NACRES:

NA.77

MDL number:

MFCD00865710

Assay:

>98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

주요 문서

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제품 이름

Fexofenadine hydrochloride, >98% (HPLC)

SMILES string

Cl[H].CC(C)(C(O)=O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4

InChI key

RRJFVPUCXDGFJB-UHFFFAOYSA-N

InChI

1S/C32H39NO4.ClH/c1-31(2,30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37,26-10-5-3-6-11-26)27-12-7-4-8-13-27;/h3-8,10-13,15-18,28-29,34,37H,9,14,19-23H2,1-2H3,(H,35,36);1H

assay

>98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: soluble ≥5 mg/mL

originator

Sanofi Aventis

storage temp.

−20°C

Quality Level

100

Gene Information

human ... HRH1(3269)

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Application

Fexofenadine hydrochloride has been used as a non-cationic ampliphilic antihistamines in NCI-H661 cells and as a histamine H1 receptor antagonist in mice

Biochem/physiol Actions

Fexofenadine is used in treating allergic rhinitis and chronic idiopathic urticaria. It may give relief in bothersome symptom and is a second-generation antihistamines. Fexofenadine provides better relief compared to other antihistamines for nasal congestion. It is the active metabolite of terfenadine and bring down allergen-induced symptoms.

Fexofenadine is a non-sedating H1 histamine receptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function

Dicpinigaitis PV and Gayle YE

British Journal of Clinical Pharmacology, 56(5), 501-504 (2003)

Pharmacokinetics of fexofenadine: evaluation of a microdose and assessment of absolute oral bioavailability

Lappin G, et al.

European Journal of Pharmaceutical Sciences, 40(2), 125-131 (2010)

Repurposing cationic amphiphilic antihistamines for cancer treatment

Ellegaard AM, et al.

EBioMedicine, 9, 130-139 (2016)

Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson's disease.

Jae-Bong Kim et al.

Journal of neuroinflammation, 21(1), 53-53 (2024-02-22)

Parkinson's disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need in the treatment of PD. A clinical pharmacology-based drug repositioning

Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation

Lu Y, et al.

Molecular and Cellular Biochemistry, 406(1-2), 263-271 (2015)

모든 관련된 서류 보기

문서

Discover Bioactive Small Molecules for ADME/Tox

Fexofenadine hydrochloride

>98% (HPLC), H1 histamine receptor antagonist, powder

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI key

InChI

assay

form

storage condition

color

solubility

originator

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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