F9677
Felodipine
L-type calcium channel blocker, solid
동의어(들):
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H19NO4Cl2
CAS 번호:
Molecular Weight:
384.25
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
제품 이름
Felodipine, solid
SMILES string
CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC
InChI key
RZTAMFZIAATZDJ-UHFFFAOYSA-N
InChI
1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
form
solid
solubility
DMSO: 20 mg/mL, H2O: insoluble
originator
AstraZeneca
Quality Level
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), CACNA2D1(781), NR3C2(4306)
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General description
Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.
Biochem/physiol Actions
L-type calcium channel blocker
Features and Benefits
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation
저장 등급
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Meyler's Side Effects of Cardiovascular Drugs (2009)
Sofia A Papadimitriou et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 82(1), 175-186 (2012-06-27)
In the present study, the efficiency of PVP/PEG200 mixtures as appropriate carries for the preparation of solid dispersions by melt mixing was evaluated. Felodipine (FELO) was used as a poorly water soluble model drug. The effect of several melt mixing
Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.
Sheridan JV, et al.
British Journal of Clinical Pharmacology, 23(4), 391-396 (1987)
Sheng Qi et al.
Pharmaceutical research, 28(9), 2311-2326 (2011-05-25)
To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to submicron scale. Hot-melt-extruded felodipine and Eudragit® E PO systems at a range of compositions were studied after a standard period of aging to allow phase separation to
Nikolaos Scoutaris et al.
Journal of controlled release : official journal of the Controlled Release Society, 156(2), 179-185 (2011-08-11)
We demonstrate the viability of using an ink-jet printer to produce a formulation capable of controlling the release of a drug. This is shown for the drug felodipine, an antihypertensive, with polyvinyl pirrolidone (PVP) as an excipient. As felodipine is
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