G6649

Genistein

Name: Genistein
Brand: SIGMA

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

동의어(들):

4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₁₀O₅

CAS 번호:

446-72-0

Molecular Weight:

270.24

NACRES:

NA.77

PubChem Substance ID:

24278036

UNSPSC Code:

12352200

EC Number:

207-174-9

MDL number:

MFCD00016952

Beilstein/REAXYS Number:

263823

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

200

주요 문서

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제품 이름

Genistein, synthetic, ≥98% (HPLC), powder

InChI key

TZBJGXHYKVUXJN-UHFFFAOYSA-N

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

SMILES string

Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O

biological source

synthetic

assay

≥98% (HPLC)

form

powder

color

off-white to yellow

mp

297.0-298.0 °C

solubility

DMSO: soluble, ethanol: soluble

storage temp.

−20°C

Quality Level

200

Gene Information

human ... AKT1(207), CYP19A1(1588), EGFR(1956), ESR1(2099), ESR2(2100)
mouse ... Esr1(13982), Hexa(15211)
rat ... Adora1(29290), Adora2a(25369), Ar(24208)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

General description

Genistein is an isoflavonoid present among Leguminosae family of plants. It is structurally similar to estrogen (estradiol-17β).

Application

Genistein has been used:

as a test compound to access its estrogeniic acivity
as an oestrogenic ligand to carry out identical reporter gene activation assays and also used to examine the binding of genistein to hERβ
as an endocytosis inhibitor to test the possible effect of endocytosed advanced glycation end - bovine serum albumin (AGE-BSA) on lysosomes

Biochem/physiol Actions

Genistein is essential for plant-microbe interaction. It acts as a natural chemoprotectant and helps in preventing tumor progression and heart disorders. Genistein functionally shares estrogen′s action. It is useful in evaluating nutraceuticals and functional foods. Genistein exhibits antimicrobial action and can serve as a phytoalexin and phytoanticipin.

Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Chloride Channels and Met pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Genistein is soluble in DMSO and ethanol. It is also soluble in chlorform:methanol (1:1 (v:v), 10 mg/ml).

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Genistein

Dixon RA and Ferreira D

Phytochemistry, 60(3), 205-211 (2002)

Autophagy-lysosome pathway in renal tubular epithelial cells is disrupted by advanced glycation end products in diabetic nephropathy

Liu WJ, et al.

Test, jbc-M115 (2015)

Cloning of oestrogen receptor beta from Old and New World primates: identification of splice variants and functional analysis

Sierens JE, et al.

Journal of Molecular Endocrinology, 32(3), 703-718 (2004)

Assaying estrogenicity by quantitating the expression levels of endogenous estrogen-regulated genes.

Jorgensen M, et al.

Environmental Health Perspectives, 108(5), 403-403 (2000)

Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression.

Haolong Li et al.

Oncotarget, 6(24), 20474-20484 (2015-05-27)

Although the new generation of androgen receptor (AR) antagonists like enzalutamide (ENZ) prolong survival of metastatic castration-resistant prostate cancer (CRPC), AR-driven tumors eventually recur indicating that additional therapies are required to fully block AR function. Since DNA topoisomerase II (Topo

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Genistein

≥98% (HPLC), powder, tyrosine protein kinase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

biological source

assay

form

color

mp

solubility

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Features and Benefits

Preparation Note

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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