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Merck

G7403

Glycine

≥99% (titration), suitable for electron microscopy, BioXtra

동의어(들):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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제품정보 (DICE 배송 시 비용 별도)

Linear Formula:
NH2CH2COOH
CAS 번호:
Molecular Weight:
75.07
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-272-2
MDL number:
Beilstein/REAXYS Number:
635782
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제품 이름

Glycine, BioXtra, ≥99% (titration)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

SMILES string

NCC(O)=O

product line

BioXtra

assay

≥99% (titration)

form

powder

technique(s)

electron microscopy: suitable

impurities

Insoluble matter, passes filter test

ign. residue

≤0.05%

loss

≤0.05% loss on drying, HV, 20-26 °C

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

solubility

1 M HCl: 1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.005%, sulfate (SO42-): ≤0.005%

cation traces

Al: ≤0.0005%, As: ≤0.00001%, Ba: ≤0.0005%, Bi: ≤0.0005%, Ca: ≤0.001%, Cd: ≤0.0005%, Co: ≤0.0005%, Cr: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Li: ≤0.0005%, Mg: ≤0.0005%, Mn: ≤0.0005%, Mo: ≤0.0005%, NH4+: ≤0.02%, Na: ≤0.02%, Ni: ≤0.0005%, Pb: ≤0.0005%, Sr: ≤0.0005%, Zn: ≤0.0005%

absorption

≤0.04 at 260 in 1 M HCl at 1 M, ≤0.04 at 280 in 1 M HCl at 1 M

UV absorption

λ: 260 nm Amax: ≤0.04, λ: 260 nm Amax: 0.003, λ: 260 nm Amax: 0.006

Quality Level

Gene Information

rat ... Grin2a(24409)

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Application

Glycine has been used to quench unreacted aldehyde during sample (nuclei) preparation for scanning electron microscope. It has also been used for sample fixation in the process of immunolabeling.

Biochem/physiol Actions

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.
Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Visualization of the nucleus and nuclear envelope in situ by SEM in tissue culture cells.
Allen TD
Nature Protocols, 2(5), 1180-1184 (2007)
Pre-embedding immunogold labeling to optimize protein localization at subcellular compartments and membrane microdomains of leukocytes.
Melo RC
Nature Protocols, 9(10), 2382-2394 (2014)
Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation
Mohit Jain
Science, 336(6084), 1040-1044 (2012)
Alexander Carvajal-González et al.
Brain : a journal of neurology, 137(Pt 8), 2178-2192 (2014-06-22)
The clinical associations of glycine receptor antibodies have not yet been described fully. We identified prospectively 52 antibody-positive patients and collated their clinical features, investigations and immunotherapy responses. Serum glycine receptor antibody endpoint titres ranged from 1:20 to 1:60 000.
Bethany L Johnson-Kerner et al.
Human molecular genetics, 24(5), 1420-1431 (2014-11-16)
Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease caused by autosomal recessive mutations in the GAN gene resulting in a loss of a ubiquitously expressed protein, gigaxonin. Gene replacement therapy is a promising strategy for treatment of the disease;

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