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Merck

G8377

Guanosine 5′-monophosphate disodium salt hydrate

≥99%,from yeast, powder

동의어(들):

5′-GMP-Na2, 5′-Guanylic acid disodium salt hydrate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C10H12N5Na2O8P · xH2O
CAS 번호:
Molecular Weight:
407.18 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
226-914-1
MDL number:
Beilstein/REAXYS Number:
3586801
Assay:
≥99%
Biological source:
yeast
Form:
powder
Solubility:
H2O: soluble 50 mg/mL, clear, colorless to faintly yellow
Storage temp.:
room temp
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제품 이름

Guanosine 5′-monophosphate disodium salt hydrate, from yeast, ≥99%

biological source

yeast

Quality Level

assay

≥99%

form

powder

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

storage temp.

room temp

SMILES string

O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H14N5O8P.2Na.H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;;1H2/q;2*+1;/p-2/t3-,5-,6-,9-;;;/m1.../s1

InChI key

MEKWJTZTMVQYSU-CYCLDIHTSA-L

Application

Guanosine 5′-monophosphate is suitable for use in:
  • the measurement of density and viscosity of nucleotide and along with the furanose sugar from 0.0004 to 0.0014mol/kg solution at 288.15, 293.15 and 298.15K at atmospheric pressure
  • the detection and validation of a transcreener assay for detection of AMP- and GMP-producing enzymes
  • the preparation of nucleotide standard during the quantitative profiling of nucleotides using capillary IC-MS/MS

Biochem/physiol Actions

Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Guanosine-5′-monophosphate (GMP) can be used to study modulation of glutamatergic neurotransmission.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.


저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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문서 라이브러리 방문


프로토콜

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.


Marcelo Ganzella et al.
Purinergic signalling, 8(1), 49-58 (2011-09-02)
Overstimulation of the glutamatergic system (excitotoxicity) is involved in various acute and chronic brain diseases. Several studies support the hypothesis that guanosine-5'-monophosphate (GMP) can modulate glutamatergic neurotransmission. The aim of this study was to evaluate the effects of chronically administered
Robbin R Vernooij et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 24(22), 5790-5803 (2018-01-10)
The photodecomposition mechanism of trans,trans,trans-[Pt(N3 )2 (OH)2 (py)2 ] (1, py=pyridine), an anticancer prodrug candidate, was probed using complementary Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR), transient electronic absorption, and UV/Vis spectroscopy. Data fitting using Principal Component Analysis (PCA) and
Roberto Farina Almeida et al.
Pharmacology, biochemistry, and behavior, 96(3), 306-311 (2010-06-23)
The glutamatergic system has received considerable attention over the last few years as potential target to develop anxiolytic drugs. Guanine based purines (GBPs) play an important neurmodulatory effect in the glutamatergic system. Several studies have shown the ability of the