G8918
Anti-GRP78/BiP (GL-19) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
동의어(들):
Anti-78-kDa Glucose-Regulated Protein, Anti-Immunoglobulin Heavy Chain Binding Protein
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, ICC, WB
Citations:
36
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 78 kDa
species reactivity
mouse, hamster, human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
technique(s)
immunocytochemistry: 1:1,000 using mouse fibroblasts NIH3T3 cells, microarray: suitable, western blot: 1:3,000 using human epitheloid carcinoma HeLa whole cell extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HSPA5(3309)
mouse ... Hspa5(14828)
General description
GRP78/BiP is a Ca2+-binding molecular chaperone located in the endoplasmic reticulum (ER). It is a highly conserved protein.
Application
Anti-GRP78/BiP (GL-19) antibody produced in rabbit has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
Biochem/physiol Actions
GRP78 (78-kDa glucose-regulated protein) is essential for cell viability. GRP78/BiP is induced by stress-inducing agents or by conditions that adversely affect endoplasmic reticulum(ER) function, including oxidative stress, chemical toxicity, Ca2+ ionophores, inhibition of the ER Ca2+ -ATPase, inhibitors of glycosylation and hypoxia. GRP78/BiP is critical for maintenance of Ca2+ homeostasis and the prevention of apoptosis. GRP78/BiP levels are reduced in Alzheimer′s disease brains and the decreased expression of GRP78/BiP is found associated with mis-sense mutations in presenilin-1 (PS-1).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease
Wang WX, et al.
The American Journal of Pathology, 177(1), 334-345 (2010)
GRP78 at the centre of the stage in cancer and neuroprotection
Casas, Caty
Frontiers in Neuroscience, 11, 177-177 (2017)
Mina Thon et al.
Scientific reports, 6, 34312-34312 (2016-09-30)
Leptin, an adipocyte-derived hormone, centrally regulates energy homeostasis. Overlaps in the regulation of glucose and energy homeostasis have been reported between leptin and insulin. However, the effects of insulin on leptin's actions in the central nervous system (CNS) have not
BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation
Brennan LA, et al.
Experimental Eye Research, 174, 173-184 (2018)
Overexpressing GRP78 influences Ca2+ handling and function of mitochondria in astrocytes after ischemia-like stress
Ouyang YB, et al.
Mitochondrion, 11(2), 279-286 (2011)
관련 콘텐츠
Instructions
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