H7125
Histamine
≥97% (TLC), powder, H₁ and H₂ histamine receptor agonist
동의어(들):
2-(4-Imidazolyl)ethylamine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C5H9N3
CAS 번호:
Molecular Weight:
111.15
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352116
EC Number:
200-100-6
MDL number:
Beilstein/REAXYS Number:
2012
제품 이름
Histamine, ≥97.0%
InChI key
NTYJJOPFIAHURM-UHFFFAOYSA-N
InChI
1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
SMILES string
NCCc1c[nH]cn1
assay
≥97.0%
bp
167 °C/0.8 mmHg (lit.)
mp
83-84 °C (lit.)
storage temp.
−20°C
Quality Level
Gene Information
human ... CA1(759), CA2(760), HRH1(3269), HRH2(3274), HRH3(11255), HRH4(59340)
rat ... Hrh1(24448), Hrh3(85268)
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General description
Histamine is a neurotransmitter produced by neurons of the posterior hypothalamus. In the brain, histamine is predominantly present in the gray matter.
Application
Histamine has been used:
- to stimulate regulated cellular secretion
- in reaction mixture to activate blood for assaying thrombin (factor iia) activity by fluorimetry
- to fill the luminal side of the chamber to investigate its effects on the TJ-related barrier and the expression of TJ (tight junction) markers in the vocal fold epithelium
Biochem/physiol Actions
Endogenous H1 and H2 histamine receptor agonist; H1 activation mobilizes Ca2+; H2 activation stimulates adenylate cyclase activity in neurons; activates nitric oxide synthetase; potent vasodilator.
Endogenous H1 and H2 histamine receptor agonist; activates nitric oxide synthetase; potent vasodilator.
Histamine participates in innate and acquired immune response, mediating allergy and inflammation. It helps in intestinal muscle contraction. During anaphylactic shock histamine causes bronchial constriction. Histamine is also involved in gastric acid secretion, epithelial and endothelial barrier control.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Tight junction-related barrier contributes to the electrophysiological asymmetry across vocal fold epithelium
Zhang Q and Fisher K
PLoS ONE, 7(3), e34017-e34017 (2012)
Phospholipase D1 is specifically required for regulated secretion of von Willebrand factor from endothelial cells
Disse J, et al.
Blood, 113(4), 973-980 (2009)
Rogier A Smits et al.
Journal of medicinal chemistry, 51(8), 2457-2467 (2008-03-25)
Using a previously reported flexible alignment model we have designed, synthesized, and evaluated a series of compounds at the human histamine H 4 receptor (H 4R) from which 2-(4-methyl-piperazin-1-yl)-quinoxaline ( 3) was identified as a new lead structure for H
Rogier A Smits et al.
Journal of medicinal chemistry, 53(6), 2390-2400 (2010-03-03)
Hit optimization of the class of quinazoline containing histamine H(4) receptor (H(4)R) ligands resulted in a sulfonamide substituted analogue with high affinity for the H(4)R. This moiety leads to improved physicochemical properties and is believed to probe a distinct H(4)R
Surfactants attenuate gas embolism-induced thrombin production
Eckmann DM and Diamond SL
Anesthesiology, 100(1), 77-84 (2004)
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