H7540

Anti-Huntingtin Disease (HD/HTT) Antibody

Name: Anti-Huntingtin Disease (HD/HTT) Antibody
Brand: SIGMA

rabbit polyclonal

동의어(들):

Anti-HD, Anti-HTT, Anti-Huntington Disease, Anti-IT15

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

UNSPSC Code:

12352203

NACRES:

NA.41

주요 문서

모든 문서 보기

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제품 이름

Anti-Huntingtin (N-terminal) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~110 kDa

species reactivity

mouse, human, rat

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.5-1.0 μg/mL using a HEK-293T cell lysate expressing a N-terminal fragment of human huntingtin

UniProt accession no.

P42858

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... HTT(3064)
mouse ... Htt(15194)
rat ... Htt(29424)

General description

Anti-Huntingtin (N-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human huntingtin, conjugated to KLH.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-Huntingtin (N-terminal) antibody has been used:

in magnetic bead-assisted immunopurification
in western blotting
in immunofluorescent staining
in immunoblotting

Biochem/physiol Actions

Huntingtin (Htt) is essential for embryonic development and neurogenesis. Htt associates with various cell organelles like the nucleus, endoplasmic reticulum and Golgi complex. It is also found in neurites and synapses where it associates with vesicular structures and microtubules, suggesting that it may play a role in intracellular vesicular trafficking, calcium homeostasis, neuronal survival, morphogenesis and transcriptional regulation. Aberrant expansion of glutamine repeats (polyQ) in the N-terminal region of huntingtin (htt) causes Huntington′s disease (HD) which is an autosomal dominant neurodegenerative disorder.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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저장 등급

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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문서 라이브러리 방문

Introducing an expanded CAG tract into the huntingtin gene causes a wide spectrum of ultrastructural defects in cultured human cells

Morozova K N, et al.

PLoS ONE, 13(10), e0204735-e0204735 (2018)

An Intrabody Drug (rAAV6-INT41) Reduces the Binding of N-Terminal Huntingtin Fragment(s) to DNA to Basal Levels in PC12 Cells and Delays Cognitive Loss in the R6/2 Animal Model.

I Alexandra Amaro et al.

Journal of neurodegenerative diseases, 2016, 7120753-7120753 (2016-09-07)

Huntington's disease (HD) is a fatal progressive disease linked to expansion of glutamine repeats in the huntingtin protein and characterized by the progressive loss of cognitive and motor function. We show that expression of a mutant human huntingtin exon-1-GFP fusion

Normal huntingtin function: an alternative approach to Huntington's disease

Cattaneo E, et al.

Nature Reviews. Neuroscience, 6(12), 919-919 (2005)

Prefibrillar huntingtin oligomers isolated from HD brain potently seed amyloid formation

Morozova O A, et al.

Febs Letters, 589(15), 1897-1903 (2015)

Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.

Luisa Massai et al.

BMC biochemistry, 14, 34-34 (2013-11-28)

Huntington's disease (HD) is a monogenic disorder caused by an aberrant expansion of CAG repeats in the huntingtin gene (HTT). Pathogenesis is associated with expression of the mutant (mHTT) protein in the CNS, with its levels most likely related to

모든 관련된 서류 보기

Anti-Huntingtin Disease (HD/HTT) Antibody

rabbit polyclonal

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

enhanced validation

concentration

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

관련 카테고리

설명

General description

Physical form

Application

Biochem/physiol Actions

Disclaimer

안전성 정보

저장 등급

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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