H8876
5-Hydroxyindole-3-acetic acid
≥98% (HPLC), crystalline
동의어(들):
5-HIAA
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C10H9NO3
CAS 번호:
Molecular Weight:
191.18
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
200-195-4
MDL number:
Beilstein/REAXYS Number:
168797
제품 이름
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline
InChI key
DUUGKQCEGZLZNO-UHFFFAOYSA-N
InChI
1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
SMILES string
OC(=O)Cc1c[nH]c2ccc(O)cc12
assay
≥98% (HPLC)
form
crystalline
color
white to purple
mp
161-164 °C (dec.) (lit.)
storage temp.
−20°C
Quality Level
Gene Information
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관련 카테고리
General description
5-Hydroxyindole-3-acetic acid (5-HIAA) is the catabolic end product of serotonin pathway. 5-HIAA is present in body fluids like cerebrospinal fluid (CSF), blood and urine. The expression levels of 5-HIAA is different among the normal and cancer patients. Sepiapterin reductase deficiency results in low level of 5-HIAA in CSF. 5-HIAA level is low in CSF in patients with bipolar 1 disorder with childhood attention-deficit hyperactivity disorder (ADHD).
Application
5-Hydroxyindole-3-acetic acid has been used as standard for the measurement of 5-HIAA in the brain tissue of mice using high performance liquid chromatography (HPLC).
Biochem/physiol Actions
Major serotonin metabolite.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Nam H, et al.
Bioinformatics, 25(23), 3151-3157 (2009)
Lower CSF HVA and 5-HIAA in bipolar disorder type 1 with a history of childhood ADHD
Ryden E, et al.
Journal of neural transmission (Vienna, Austria : 1996), 116(12), 1667-1674 (2009)
Qing-Feng Xie et al.
Journal of ethnopharmacology, 144(3), 567-575 (2012-10-06)
Radix Astragali (root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, RA), Radix Angelicae sinensis (root of Angelica sinensis (Oliv.) Diels, RAS) and Folium Epimedii (leaves of Epimedium brevicomum Maxim., FE) are three of the extensively applied herbal remedies
문서
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
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