I2764
ML-7
≥98% (TLC), myosin light chain kinase inhibitor, powder
동의어(들):
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H17IN2O2S · HCl
CAS 번호:
Molecular Weight:
452.74
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
ML-7, powder
SMILES string
Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3
InChI
1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
InChI key
KDDALCDYHZIZMH-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
color
white
solubility
ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Gene Information
human ... MYLK(4638), MYLK2(85366)
Application
ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.
Biochem/physiol Actions
Selective myosin light chain kinase inhibitor.
Features and Benefits
This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Chuanjun Huang et al.
Molecular medicine reports, 17(5), 6293-6300 (2018-03-08)
Previous studies have indicated that smooth muscle myosin light chain kinase (MLCK) has a prominent role in the regulation of smooth muscle contraction, which tends to be upregulated in asthma. In recent years, numerous studies have reported that MLCK is
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.