I7018

3-Isobutyl-1-methylxanthine

Name: 3-Isobutyl-1-methylxanthine
Brand: SIGMA

≥99%, Phosphodiesterase inhibitor

동의어(들):

1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione, IBMX

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₀H₁₄N₄O₂

CAS 번호:

28822-58-4

Molecular Weight:

222.24

NACRES:

NA.77

PubChem Substance ID:

24896107

UNSPSC Code:

12352202

EC Number:

249-259-3

MDL number:

MFCD00005584

Beilstein/REAXYS Number:

247859

주요 문서

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제품 이름

3-Isobutyl-1-methylxanthine, BioUltra, ≥99%

InChI key

APIXJSLKIYYUKG-UHFFFAOYSA-N

InChI

1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)

SMILES string

CC(C)CN1C(=O)N(C)C(=O)c2[nH]cnc12

product line

BioUltra

assay

≥99%

impurities

<0.005% Phosphorus (P)

ign. residue

<0.1%

mp

200-201 °C (lit.)

solubility

DMSO: soluble 1 M (with gentle warming)

anion traces

sulfate (SO₄^2-): <0.05%

cation traces

Al: <0.0005%
Ca: <0.005%
Cu: <0.0005%
Fe: <0.005%
K: <0.05%
Mg: <0.005%
NH₄⁺: <0.05%
Na: <0.005%
Pb: <0.001%
Zn: <0.0005%

storage temp.

−20°C

Quality Level

200

Gene Information

rat ... Adora1(29290), Adora2a(25369)

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Application

3-Isobutyl-1-methylxanthine, an inhibitor of adenosine 3′,5′-cyclic monophosphate phosphodiesterase (cAMP PDE), has been used:

for adipogenic differentiation
in tissue culture
3T3-L1 preadipocyte differentiation(

Biochem/physiol Actions

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA, leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC₅₀: 1.3 μM). IBMX also serves as an adenosine receptor antagonist. IBMX has been shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. IBMX induces calcium release from intracellular stores in sensory neurons.

Features and Benefits

Trace element testing by ICP
ICP testing for trace sulfur (as sulfate) and phosphorus (as phosphate) content
Ion chromatography testing for trace ammonium content

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity

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Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells

Sembongi H, et al.

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Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces

Li X, et al.

PLoS ONE, 6(10), e26029-e26029 (2011)

Regulation of sheep oocyte maturation using cAMP modulators.

Ryan D Rose et al.

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모든 관련된 서류 보기

3-Isobutyl-1-methylxanthine

≥99%, Phosphodiesterase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

InChI

SMILES string

product line

assay

impurities

ign. residue

mp

solubility

anion traces

cation traces

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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