L0668
Anti-LAMP2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
동의어(들):
Anti-CD107B, Anti-LGP110, Anti-Lysosomal Membrane Glycoprotein-type B (LGP-B), Anti-Lysosome-Associated Membrane Protein 2
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB CL
Citations:
51
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~110 kDa
species reactivity
human (predicted), mouse, rat
technique(s)
indirect immunofluorescence: 10-20 μg/mL using rat NRK and mouse NIH3T3 cells, western blot (chemiluminescent): 2.5-5 μg using whole extract of rat NRK cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... LAMP2(3920)
mouse ... Lamp2(16784)
rat ... Lamp2(24944)
General description
LAMP2 (lysosome-associated membrane protein 2) is a heavily glycosylated intrinsic protein (110kD) present in lysosomal membrane. The protein glycosylation is essential for its function to protect the lysosomal membrane from proteolytic enzymes. Anti-LAMP2 antibody can be used in western blotting. It can also be used as a lysosomal marker. Rabbit anti-LAMP2 antibody reacts specifically with LAMP2 of mouse and rat.
LAMP2 encodes a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome.
Lysosomal associated membrane protein 2 (LAMP2) gene is located on human chromosome Xq24. LAMP2 is majorly expressed in lysosomes. It has three isoforms, that is LAMP2A, LAMP2B and LAMP2C.
Immunogen
synthetic peptide corresponding to amino acid residues 404-415 of mouse LAMP2 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in rat and differs by two amino acids in human.
Application
Anti-LAMP2 antibody can be used in immunofluorescence and immunoblotting
Anti-LAMP2 antibody produced in rabbit has been used in immunohistochemical analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Lysosomal associated membrane protein 2 (LAMP2) promotes cell-cell adhesion. It maintains cellular homeostasis and stress.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Ke-Qiong Deng et al.
Circulation, 137(14), 1486-1504 (2017-12-13)
Cardiac hypertrophy and its resultant heart failure are among the most common causes of mortality worldwide. Abnormal protein degradation, especially the impaired lysosomal degradation of large organelles and membrane proteins, is involved in the progression of cardiac hypertrophy. However, the
Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
Peschel A, et al.
Journal of the American Society of Nephrology, 25(3), 455-463 (2014)
Acute alloxan renal toxicity in the rat initially causes degeneration of thick ascending limbs of Henle
Terayama Y, et al.
Journal of Toxicologic Pathology (2016)
Surface LAMP-2 is an endocytic receptor that diverts antigen internalized by human dendritic cells into highly immunogenic exosomes
Leone DA, et al.
Journal of Immunology, ji1601263-ji1601263 (2017)
B L Granger et al.
The Journal of biological chemistry, 265(20), 12036-12043 (1990-07-15)
lgp110 is a heavily glycosylated intrinsic protein of lysosomal membranes. Initially defined by monoclonal antibodies against mouse liver lysosomes, it consists of a 45-kilodalton core polypeptide with O-linked and 17 asparagine-linked oligosaccharide side chains in mouse cells. Sialic acid residues
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Datasheet
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