L5288
Latrunculin B
from Latruncula magnifica, ≥80% (HPLC), solid, actin polymerization inhibitor
동의어(들):
LAT-B
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C20H29NSO5
CAS 번호:
Molecular Weight:
395.51
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
Latrunculin B from Latruncula magnifica, ≥80% (HPLC), solid
SMILES string
C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CCC=C1
InChI key
NSHPHXHGRHSMIK-JRIKCGFMSA-N
InChI
1S/C20H29NO5S/c1-13-5-3-4-6-14(2)9-18(22)25-16-10-15(8-7-13)26-20(24,11-16)17-12-27-19(23)21-17/h3,5,9,13,15-17,24H,4,6-8,10-12H2,1-2H3,(H,21,23)/b5-3-,14-9-/t13-,15-,16-,17+,20-/m1/s1
assay
≥80% (HPLC)
form
solid
mol wt
395.5
solubility
ethanol: soluble
storage temp.
−20°C
Quality Level
Application
Latrunculin B from Latruncula magnifica has been used for actin depolymerisation in various experiments. It has also been used as a component in bone marrow-derived dendritic cell (BMDC) complete medium, to study the formation of tubules from phagosomes in dendritic cells.
Biochem/physiol Actions
Latrunculin B inhibits actin polymerization in vitro. Latrunculin B disrupts microfilament-mediated processes.
General description
Latrunculin B is a macrocyclic toxin, which is produced by Latruncula magnifica.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Development of the theta comparative cell scoring method to quantify diverse phenotypic responses between distinct cell types
Warchal SJ, et al.
Assay and Drug Development Technologies, 14(7), 395-406 (2016)
Synthesis of Essential Drugs (2012)
Visualizing toll-like receptor-dependent phagosomal dynamics in murine dendritic cells using live cell microscopy
Mantegazza AR and Marks MS
Methods in Molecular Biology, 191-203 (2015)
Li-Kun Phng et al.
Development (Cambridge, England), 140(19), 4031-4040 (2013-09-21)
Actin filaments are instrumental in driving processes such as migration, cytokinesis and endocytosis and provide cells with mechanical support. During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration
Microtubule-dependent targeting of the exocyst complex is necessary for xylem development in Arabidopsis
Vukavsinovic N, et al.
The New phytologist, 213(3), 1052-1067 (2017)
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