L6785

Lactacystin

Name: Lactacystin
Brand: SIGMA

≥90% (HPLC), powder, proteosome inhibitor

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₅H₂₄N₂O₇S

CAS 번호:

133343-34-7

Molecular Weight:

376.43

UNSPSC Code:

12352200

PubChem Substance ID:

24896445

NACRES:

NA.77

MDL number:

MFCD01076525

Assay:

≥90% (HPLC)

Form:

powder

Quality level:

200

주요 문서

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제품 이름

Lactacystin, ≥90% (HPLC)

SMILES string

CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O

InChI

1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1

InChI key

DAQAKHDKYAWHCG-RWTHQLGUSA-N

assay

≥90% (HPLC)

form

powder

potency

4 nM K_i (proteasome inhibitor)

solubility

water: 10 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

Application

Lactacystin has been used:

as a proteasome inhibitor to inhibit protein degradation
to inhibit proteasomal activity of cells for live cell imaging
to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
to provide unilateral injection to animals to induce nigrostriatal lesions

Biochem/physiol Actions

Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor for clasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.

General description

Lactacystin is an antibiotic and a metabolite of Streptomyces spp.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Evolution of extra-nigral damage predicts behavioural deficits in a rat proteasome inhibitor model of Parkinson's disease

Vernon A C, et al.

PLoS ONE, 6(2), e17269-e17269 (2011)

Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells

Landsverk O J B, et al.

Journal of Leukocyte Biology, 91(5), 729-737 (2012)

Proteasome function is required for platelet production.

Dallas S Shi et al.

The Journal of clinical investigation, 124(9), 3757-3766 (2014-07-26)

The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin A CENTRAL ROLE FOR clasto-LACTACYSTIN beta-LACTONE

Dick L R, et al.

The Journal of Biological Chemistry, 271(13), 7273-7276 (1996)

The development and pharmacology of proteasome inhibitors for the management and treatment of cancer

Ruggeri B, et al.

Advances in Pharmacology, 57(13), 91-135 (2009)

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문서

Irreversible Inhibitors

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

비가역적 억제제

비가역적 억제제에 속하는 자살 억제제, 중금속 억제제, 시간 의존적 억제제 등의 정의와 용도에 대해 알아보세요.

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Lactacystin

≥90% (HPLC), powder, proteosome inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

assay

form

potency

solubility

storage temp.

Quality Level

관련 카테고리

설명

Application

Biochem/physiol Actions

General description

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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