Sodium L-lactate

Sodium L-lactate has been used:

• as a medium supplement and cell fuel source for human mammary epithelial cell line(MCF10A) and dendritic cell culture
• as a gluconeogenic substrate in hepatic glucose production assay in primary hepatocytes
• in the glucose production medium for glucose production assay in human embryonic kidney (HEK293T) cells
• as a standard for calibration in lactate assay in bone marrow-derived macrophages

L-lactate is produced from pyruvate by the enzyme lactate dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells.

Versatile and adaptable for a wide variety of laboratory and research applications

Sodium L-lactate, an organic acid derived from L-lactic acid, naturally occurs in the body, contributing to pH regulation, acid-base equilibrium, and various physiological processes, including energy metabolism through the Cori cycle. Its versatile properties extend to antimicrobial action by creating an acidic environment that inhibits harmful bacterial growth. In metabolic pathways, Sodium L-lactate exhibits efficient conversion for energy production, potentially surpassing glucose uptake in certain instances, utilizing fatty acids as an alternative fuel source, and stimulating mitochondria for enhanced ATP production, indicating a role in optimizing cellular energy efficiency. Moreover, research suggests neuroprotective capabilities, safeguarding neuronal cells from high-fat diet-induced death and addressing potential links to obesity-related neurodegenerative issues.

This multifaceted nature of Sodium L-lactate positions it as a valuable molecule for research in cellular metabolism, neuroprotection, antimicrobial, and nutritional science, where its diverse properties, including efficient energy conversion, neuroprotective effects, and potent antimicrobial activity contribute to a deeper understanding across these scientific domains.

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