L7757
Lidocaine
≥98% (GC), powder, neuroprotective agent
동의어(들):
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C14H22N2O
CAS 번호:
Molecular Weight:
234.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-302-8
MDL number:
제품 이름
Lidocaine, powder
InChI key
NNJVILVZKWQKPM-UHFFFAOYSA-N
InChI
1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
SMILES string
CCN(CC)CC(=O)Nc1c(C)cccc1C
form
powder
Quality Level
Gene Information
human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)
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관련 카테고리
Application
Lidocaine may be used for drug testing and for voltage clamp experiments.
Biochem/physiol Actions
Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Na+ channel blocker; class IB antiarrhythmic.
General description
Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Pharmacokinetics and pharmacodynamics of lignocaine: a review
Weinberg L, et al.
World Journal of Anesthesiology, 4(2), 17-29 (2015)
Mitochondrial injury and caspase activation by the local anesthetic lidocaine
Johnson ME, et al.
Anesthesiology, 101(5), 1184-1194 (2004)
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)
Cytotoxicity of lidocaine to human corneal endothelial cells in vitro
Yu HZ, et al.
Basic and Clinical Pharmacology and Toxicology, 114(4), 352-359 (2014)
Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia
Lei B, et al.
Anesthesiology, 95(2), 445-451 (2001)
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