M1523
Muscimol
≥98% (TLC), powder, GABAA receptor agonist.
동의어(들):
3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C4H6N2O2
CAS 번호:
Molecular Weight:
114.10
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
220-430-4
MDL number:
Beilstein/REAXYS Number:
1618960
Form:
powder
Quality level:
제품 이름
Muscimol, powder
InChI key
ZJQHPWUVQPJPQT-UHFFFAOYSA-N
InChI
1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
SMILES string
NCC1=CC(=O)NO1
form
powder
color
white to off-white
storage temp.
2-8°C
Quality Level
Gene Information
rat ... Gabra2(29706)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
Application
Muscimol has been used:
- to reduce conditioned fear-expression in lateral amygdala (LA)
- to eliminate cortical cell response in ferrets
- to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches
Biochem/physiol Actions
GABAA receptor agonist.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - STOT SE 3
target_organs
Central nervous system
저장 등급
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Su-Hyuk Ko et al.
International journal of molecular sciences, 21(22) (2020-11-19)
Autophagy is a conserved pathway that plays a key role in cell homeostasis in normal settings, as well as abnormal and stress conditions. Autophagy dysfunction is found in various neurodegenerative diseases, although it remains unclear whether autophagy impairment is a
Julen Hernandez-Lallement et al.
Current biology : CB, 30(6), 949-961 (2020-03-07)
Empathy, the ability to share another individual's emotional state and/or experience, has been suggested to be a source of prosocial motivation by attributing negative value to actions that harm others. The neural underpinnings and evolution of such harm aversion remain
Handbook of Mushroom Poisoning: Diagnosis and Treatment (1994)
The role of the lateral amygdala in the retrieval and maintenance of fear-memories formed by repeated probabilistic reinforcement
Erlich JC, et al.
Frontiers in Behavioral Neuroscience, 6, 16-16 (2012)
Relation of cortical cell orientation selectivity to alignment of receptive fields of the geniculocortical afferents that arborize within a single orientation column in ferret visual cortex
Chapman B, et al.
The Journal of Neuroscience, 11(5), 1347-1358 (1991)
문서
신경과학을 위한 생체 활성 저분자
DISCOVER Bioactive Small Molecules for Neuroscience
관련 콘텐츠
Instructions
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.