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Merck

M1547

Metronidazole

BioXtra

동의어(들):

2-Methyl-5-nitroimidazole-1-ethanol

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C6H9N3O3
CAS 번호:
443-48-1
Molecular Weight:
171.15
UNSPSC Code:
51282808
NACRES:
NA.76
PubChem Substance ID:
24896667
EC Number:
207-136-1
Beilstein/REAXYS Number:
611683
MDL number:
MFCD00009750

주요 문서

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InChI

1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3

InChI key

VAOCPAMSLUNLGC-UHFFFAOYSA-N

SMILES string

CC1=NC=C([N+]([O-])=O)N1CCO

product line

BioXtra

impurities

≤0.2% Total Impurities

ign. residue

≤0.1%

color

white to light yellow

Quality Level

200

solubility

acetic acid: 0.1 M, clear, colorless to yellow

anion traces

chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.01%, Pb: ≤0.001%, Zn: ≤0.0005%

antibiotic activity spectrum

Gram-negative bacteria, parasites

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

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관련 카테고리

General description

Chemical structure: imidazole

Application

Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.

Biochem/physiol Actions

Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.

pictograms

Health hazard
GHS08

signalword

Danger

Hazard Classifications

Carc. 1B - Muta. 1B - STOT RE 2

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
0000512471
0000512480
0000490355
0000490355
0000485816

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