Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit

Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.

Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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