M1946

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit

Name: Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution

동의어(들):

Anti-Adrenalin oxidase, Anti-MAO, brain, Anti-MAO, platelet, Anti-Tyramine oxidase

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

western blot

Species reactivity:

rat, mouse, human

Citations:

Technique(s):

western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B

Uniprot accession no.:

P27338

주요 문서

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제품 이름

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit, affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~58 kDa

species reactivity

rat, mouse, human

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 0.25-0.5 μg/mL using rat liver mitochondrial fraction and HEK-293T cells expressing human MAO-B

UniProt accession no.

P27338

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... ASCC3(10973), MAOB(4129)
rat ... Maob(25750)

Application

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Anti-Monoamine Oxidase B (C-terminal) specifically recognizes human, mouse and rat MAO-B.

Monoamine oxidases (MAOs) are the main degradative enzymes responsible for the oxidative deamination of biogenic amines, such as epinephrine, norepinephrine, serotonin (5-HT) and dopamine in the central nervous system (CNS) and peripheral tissues. MAO-B is considered the predominant isoform responsible for dopamine metabolism in the human CNS. It participates in the metabolism of neuroactive and vasoactive amines. MAO-B activity correlates with personality traits. Alterations in MAO-B activity may underlie dopamine pathobiology in major depression. Selective MAO-B inhibitors elevate synaptosomal dopamine concentrations and have recently shown clinical efficacy in the treatment of early Parkinson′s disease.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Anti-Monoamine Oxidase B (C-terminal) is produced in rabbit using as immunogen a synthetic peptide corresponding to human monoamine oxidase B (MAO-B) conjugated to KLH. Monoamine oxidases (MAOs) are mitochondrial flavoprotein enzymes, localized to the mitochondrial outer membrane. MAO-B is mainly found in the brain in dopaminergic, serotonergic and histaminergic neurons, as well as in astrocytes. It is a member of the flavin monoamine oxidase family. MAOB gene is mapped to human chromosome Xp11.

Physical form

Supplied as a solution in 0.01 M PBS, pH 7.4, containing 15 mM sodium azide as a preservative.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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저장 등급

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

098M4801V

21180639

028K4785

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리 방문

Investigating association of four gene regions (GABRB3, MAOB, PAH, and SLC6A4) with five symptoms in schizophrenia

Sun J, et al.

Psychiatry Research, 198(2), 202-206 (2012)

PET imaging for addiction medicine: From neural mechanisms to clinical considerations

Wiers CE, et al.

Progress in Brain Research, 224, 175-201 (2016)

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology

Mallajosyula JK, et al.

PLoS ONE, 3(2), e1616-e1616 (2008)

A linkage study of schizophrenia to markers within Xp11 near the MAOB gene

Dann J, et al.

Psychiatry Research, 70(3), 131-143 (1997)

Molecular and Mechanistic Properties of the Membrane-Bound Mitochondrial Monoamine Oxidases

Edmondson DE, et al.

Biochemistry, 48(20), 4220-4220 (2009)

모든 관련된 서류 보기

Anti-Monoamine Oxidase B (C-terminal) antibody produced in rabbit

affinity isolated antibody, ~1.5 mg/mL, buffered aqueous solution

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

biological source

conjugate

antibody form

antibody product type

clone

form

mol wt

species reactivity

packaging

enhanced validation

concentration

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Disclaimer

General description

Physical form

Preparation Note

안전성 정보

저장 등급

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

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