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Merck

M2574

Meropenem trihydrate

≥98% (HPLC), powder, antibacterial agent

동의어(들):

(1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C17H25N3O5S · 3H2O
CAS 번호:
119478-56-7
Molecular Weight:
437.51
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD08600005
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

주요 문서

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제품 이름

Meropenem trihydrate, ≥98% (HPLC)

InChI key

CTUAQTBUVLKNDJ-OBZXMJSBSA-N

SMILES string

O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O

InChI

1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

originator

AstraZeneca

storage temp.

−20°C

Quality Level

100

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관련 카테고리

General description

Meropenem trihydrate (MRP) belongs to the carbapenem group of compounds. It is susceptible to degradation at high temperature and humidity. It is soluble in methanol-water or acetone-water combinations. It is used as an antibacterial agent for treating meningitis and pneumonia.

Application

Meropenem trihydrate has been used in the
  • antibiotic susceptibility testing of E coli isolates from harbor estuary sediment samples
  • in the bacterial killing assay and for screening antibiotic resistance of cystic fibrosis patient′s sputum based Staphylococcus aureus transformed macrophages in phagocyte infection
  • for screening Enterococcus faecalis from human bile

Biochem/physiol Actions

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.
Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

Lot/Batch Number
0000399409
0000399409
0000444308
0000444308
0000399408

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Lisa Kolano et al.
Chembiochem : a European journal of chemical biology, 21(18), 2628-2634 (2020-04-16)
Proline-rich antimicrobial peptides expressed in insects are primarily active against Enterobacteriaceae. Mechanistically, they target the bacterial (70S) ribosome after partially transporter-based cellular uptake, as revealed for Api137 and Onc112 on Escherichia coli. Following molecular modeling indicating that the Onc112 contact
Human bile reduces antimicrobial activity of selected antibiotics against Enterococcus faecalis and Escherichia coli in vitro
Wulkersdorfer B, et al.
Antimicrobial agents and chemotherapy, 61(8), e00527-e00517 (2017)
Measurement and correlation of solubility of meropenem trihydrate in binary (water+ acetone/tetrahydrofuran) solvent mixtures
Zhou L, et al.
Chinese Journal of Chemical Engineering, 25(10), 1461-1466 (2017)
Thanh C Tran et al.
MicrobiologyOpen, 9(12), e1130-e1130 (2020-11-10)
To assess a cost-effective in-house selective plate formula for actively screening carbapenem-resistant Enterobacteriaceae (CRE). The in-house formula included CHROMagarTM Orientation, meropenem, and ingredients present in the Mac-Conkey formula, such as bile salts and crystal violet (pH 6.9-7.2). American Type Culture
Kaivon Assani et al.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 18(5), 622-629 (2018-10-28)
There are no effective treatments for Burkholderia cenocepacia in patients with cystic fibrosis (CF) due to bacterial multi-drug resistance and defective host killing. We demonstrated that decreased bacterial killing in CF is caused by reduced macrophage autophagy due to defective
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