M3821
Anti-Myelin Basic Protein Antibody
rabbit polyclonal
동의어(들):
Anti-MBP
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
FACS, IHC, WB
Citations:
55
제품 이름
Anti-Myelin Basic Protein (MBP) antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 17-22 kDa (isoform), antigen ~22 kDa (isoform), antigen ~33 kDa (isoform)
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 1:200-1:500, immunohistochemistry: 1:100-1:200, western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MBP(4155)
mouse ... Mbp(17196)
rat ... Mbp(24547)
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관련 카테고리
General description
Myelin Basic Protein (MBP) is a hydrophilic protein that is expressed mainly in oligodendrocytes. It has a pivotal role in myelination of nervous system, signaling pathways prior to myelination and remyelination processes after neural injury. Anti-myelin basic protein (MBP) antibody can be used in western blotting and flow cytometry. Rabbit anti-myelin basic protein antibody reacts specifically with myelin basic protein of mouse, rat and human.
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of the myelin sheath and is highly expressed in central nervous system (CNS).
Immunogen
synthetic peptide corresponding to residues 102-116 of human Myelin Basic Protein.
Application
Anti-Myelin Basic Protein (MBP) antibody produced in rabbit has been used in:
- indirect immunolabeling
- immunohistochemistry.
- Western Blotting.
Anti-myelin basic protein (MBP) antibody (diluted 1:200) can be used as a primary antibody in double fluorescence labeling. It can also be used to detect myelin basic protein using immunoblotting.
Biochem/physiol Actions
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP functions as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis. MBP functions as an in vitro substrate for mitogen-activated protein kinase (MAP) kinase and aids in the purification and functional studies of enzyme.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Functional motor recovery from motoneuron axotomy is compromised in mice with defective corticospinal projections.
Ding Y, et al.
PLoS ONE, 9 (2014)
C M Deber et al.
Clinical biochemistry, 24(2), 113-134 (1991-04-01)
Multiple sclerosis (MS) and a number of related distinctive diseases are characterized by the active degradation of central nervous system (CNS) myelin, an axonal sheath comprised essentially of proteins and lipids. These demyelinating diseases appear to arise from complex interactions
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA, et al.
The Biochemical Journal, 472, 17-32 (2015)
Neuroglial Cells in Long-Term Primary Cultures from the Gilthead Seabream (Sparus Aurata L.): New Functional In Vitro Model from Bony Fish Brain
Centoducati, et al.
Italian Journal of Animal Science, 12 (2013)
Multilineage Differentiation Potential of CNS Cell Progenitors in a Recent Developed Gilthead Seabream (Sparus aurata L.) Nervous Model
Santacroce MP, et al.
Journal of bioprocessing & biotechniques null
관련 콘텐츠
Instructions
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