M4403
Anti-MAP2 Antibody
mouse monoclonal, HM-2
동의어(들):
MAP2 Antibody - Monoclonal Anti-MAP2 antibody produced in mouse, Map2 Antibody
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크기 선택
보기 변경
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
HM-2, monoclonal
Application:
IHC (p), WB
Citations:
470
제품 이름
Monoclonal Anti-MAP2 antibody produced in mouse, ascites fluid, clone HM-2
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
HM-2, monoclonal
mol wt
antigen ~280 kDa
contains
15 mM sodium azide
species reactivity
rat, chicken, human, mouse, bovine, quail
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, western blot: 1:1,000 using a fresh total rat brain extract or an enriched microtubule protein preparation
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MAP2(4133)
mouse ... Mtap2(17756)
rat ... Map2(25595)
General description
Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are three forms of MAP2; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).
Immunogen
rat brain microtubule-associated proteins (MAPs).
Application
Monoclonal Anti-MAP2 (2a+2b) antibody has been used in immunohistochemistry, immunostaining and western blotting.
Biochem/physiol Actions
Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology.
Reacts with all known forms of MAP2, namely MAP2a, MAP2b and MAP2c. Does not cross-react with other MAPs or tubulin. By immunohistochemical staining of formalin-fixed, paraffin-embedded brain tissue, the antibody shows selective labeling of dendritic trees throughout the brain.
Physical form
Supplied as ascites fluid with 15 mM sodium azide as a preservative.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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저장 등급
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
관련 콘텐츠
Instructions
Neural differentiation of mouse embryonic stem cells grown in monolayer.
Pachernik J, et al.
Reproduction, Nutrition, Development, 42(4), 317-326 (2002)
The MAP2/Tau family of microtubule-associated proteins.
Dehmelt L and Halpain S
Genome Biology, 6(1), 204-204 (2005)
GABA and histogenesis in fetal and neonatal mouse brain lacking both the isoforms of glutamic acid decarboxylase.
Ji F, et al.
Neuroscience Research, 33(3), 187-194 (1999)