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Merck

M5441

Mibefradil dihydrochloride hydrate

≥98% (HPLC), powder, T-type Ca²⁺ channel blocker

동의어(들):

(1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate, Ro 40-5967 hydrate

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C29H38FN3O3 · 2HCl · xH2O
CAS 번호:
116666-63-8
Molecular Weight:
568.55 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24278558
NACRES:
NA.77
MDL number:
MFCD11044451
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

주요 문서

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제품 이름

Mibefradil dihydrochloride hydrate, ≥98% (HPLC), powder

SMILES string

O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C

InChI key

IZSWBBGKLWFDOC-YKXHUFBBSA-N

InChI

1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: soluble >20 mg/mL
absolute ethanol: insoluble

originator

Roche

Quality Level

100

관련 카테고리

Application

Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc.

Biochem/physiol Actions

Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons.
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000436339
0000120000
0000120000
0000436339
0000104592

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Calcium channels are involved in EphB/ephrinB reverse signaling-induced apoptosis in a rat chronic ocular hypertension model
Dong L, et al.
Molecular Medicine Reports, 17(2), 2465-2471 (2018)
Mibefradil inhibition of T-type calcium channels in cerebellar purkinje neurons
McDonough S I and Bean B P
Molecular Pharmacology, 54(6), 1080-1087 (1998)
Bobbi-Jo Lowie et al.
American journal of physiology. Gastrointestinal and liver physiology, 301(5), G835-G845 (2011-08-13)
Interstitial cells of Cajal associated with the myenteric plexus (ICC-MP) are pacemaker cells of the small intestine, producing the characteristic omnipresent electrical slow waves, which orchestrate peristaltic motor activity and are associated with rhythmic intracellular calcium oscillations. Our objective was
Mibefradil block of cloned T-type calcium channels
Martin R L, et al.
Journal of Pharmacology and Experimental Therapeutics, 295(1), 302-308 (2000)
Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers
Mullins M E, et al.
JAMA : The Journal of the American Medical Association, 280(2), 157-158 (1998)
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