M5625
Menadione
crystalline
동의어(들):
2-Methyl-1,4-naphthoquinone, Vitamin K3
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H8O2
CAS 번호:
Molecular Weight:
172.18
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
200-372-6
Beilstein/REAXYS Number:
1908453
MDL number:
InChI key
MJVAVZPDRWSRRC-UHFFFAOYSA-N
InChI
1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
SMILES string
CC1=CC(=O)c2ccccc2C1=O
biological source
synthetic
assay
≥98.0% (HPLC)
form
crystalline
technique(s)
HPLC: suitable
color
faint green to green-yellow
mp
105-107 °C (lit.)
solubility
oil: soluble
storage temp.
room temp
Quality Level
Gene Information
human ... NQO1(1728)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
Application
Menadione has been used for the generation of reactive oxygen species (ROS), followed by flow cytometry analysis. It has also been used in microbiological evaluation, such as to detect fastidious microorganisms.
Biochem/physiol Actions
Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. Menadione is used as a phosphatase inhibitor and an inhibitor of mitochondrial DNA polymerase γ (pol γ). Menadione can be used as an oxidative injury (free radical generator) inducing agent.
Menadione is an aromatic polycyclic ketone. It serves as a precursor for vitamin K synthesis. Menadione is converted to menaquinone-4, an active metabolite of vitamin K3. Menadione mediates cell death, by inducing the production of reactive oxygen species through the futile redox cycling.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Investigation of cultivable bacteria isolated from longstanding retreatment-resistant lesions of teeth with apical periodontitis
Signoretti Fernanda GC, et al.
Journal of Endodontics, 39(10), 1240-1244 (2013)
Antioxidants can increase melanoma metastasis in mice
Le Gal K, et al.
Science Translational Medicine, 7(308), 308re8-308re8 (2015)
Menadione is a metabolite of oral vitamin K
Thijssen Henk HW, et al.
The British Journal of Nutrition, 95(2), 260-266 (2006)
Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis
Loor G, et al.
Free Radical Biology & Medicine, 49(12), 1925-1936 (2010)
H Thor et al.
The Journal of biological chemistry, 257(20), 12419-12425 (1982-10-25)
The cytotoxic effects of many quinones are thought to be mediated through their one-electron reduction to semiquinone radicals, which subsequently enter redox cycles with molecular oxygen to produce active oxygen species and oxidative stress. The two-electron reduction of quinones to
관련 콘텐츠
Product Information Sheet
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.