M6518
Macrophage Colony-Stimulating Factor human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
동의어(들):
MCSF
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
dimer 37 kDa
Impurities:
≤1.000 EU/μg
제품 이름
Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
0.500-5.000 ng/mL ED50
quality
endotoxin tested
mol wt
dimer 37 kDa
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1.000 EU/μg
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... CSF1(1435)
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General description
Macrophage Colony-Stimulating Factor (M-CSF) is a hematopoietic growth factor, which modulates the proliferation, differentiation and functional activation of monocytes. It is produced by fibroblasts, endothelial cells and bone marrow stromal cells. MCSF stimulates the functions of mature monocytes and macrophages.
Application
Macrophage Colony-Stimulating Factor human has been used for the differentiation of bone marrow-derived macrophages (BMDMs) and human monocyte-derived macrophages (MDMs). It has also been used for cell culture.
Biochem/physiol Actions
Macrophage colony-stimulating factor (M-CSF) augments many of the physiological functions of macrophages, and support osteoclast differentiation.
Physical form
Lyophilized from a sterile filtered buffered solution.
Analysis Note
The proliferative activity is tested in culture using the cytokine-dependent murine monocytic cell line M-NFS-60 cells.
Other Notes
159 amino acids including N-terminal methionine (each monomer).
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yuhao Liu et al.
Theranostics, 9(16), 4648-4662 (2019-08-02)
Rationale: Osteoporosis is a severe bone disorder that is a threat to our aging population. Excessive osteoclast formation and bone resorption lead to changes in trabecular bone volume and architecture, leaving the bones vulnerable to fracture. Therapeutic approaches of inhibiting
Avery's Diseases of the Newborn (2012)
GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections
Kim JK, et al.
Nature Communications, 9(1), 4184-4184 (2018)
Encyclopedia of Immunology (1998)
MIR144 inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2
Kim JK, et al.
Autophagy, 13(2), 423-441 (2017)
문서
Read article on hematopoietic cytokines and hematopoiesis
관련 콘텐츠
Datasheet
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