M7033

N^G-Methyl-L-arginine acetate salt

Name: N<SUP>G</SUP>-Methyl-<SC>L</SC>-arginine acetate salt
Brand: SIGMA

≥98% (TLC), powder, nitric oxide synthase inhibitor

동의어(들):

N_ω-Methyl-L-arginine acetate salt, L-NMMA, N⁵-(Methylamidino)-L-ornithine acetate salt, N^G-Monomethyl-L-arginine acetate salt

조직 및 계약 가격을 보려면 로그인를 클릭합니다.

크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₇H₁₆N₄O₂ · C₂H₄O₂

CAS 번호:

53308-83-1

Molecular Weight:

248.28

NACRES:

NA.77

PubChem Substance ID:

24278043

UNSPSC Code:

12352209

MDL number:

MFCD00069311

Beilstein/REAXYS Number:

6674255

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

주요 문서

모든 문서 보기

기술 서비스

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도움 문의

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도움 문의

제품 이름

N^G-Methyl-L-arginine acetate salt, ≥98% (TLC)

InChI key

IKPNWIGTWUZCKM-JEDNCBNOSA-N

SMILES string

CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1

assay

≥98% (TLC)

form

powder

solubility

water: 49.00-51.00 mg/mL, clear to very slightly hazy, colorless to faintly yellow

Quality Level

200

Gene Information

human ... NOS1(4842), NOS2(4843), NOS3(4846)
mouse ... Nos2(18126)
rat ... Nos1(24598), Nos2(24599)

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Application

N^G-Methyl-L-arginine acetate salt has been used:

as an inhibitor of nitric oxide synthase (NOS) in wound healing studies in injured mice
as an inhibitor of nitric oxide synthase (NOS) to study nitric oxide (NO) immunosuppressive effect of murine stem cells
as an inhibitor to monitor NO levels in hemocytes respiratory burst assay

Biochem/physiol Actions

N^G-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

0000490226

0000436135

0000340744

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

NG-methyl-L-arginine, an inhibitor of nitric oxide synthase, affects the central nervous system to produce peripheral hyperglycemia in conscious rats

Uemura K, et al.

Neuroendocrinology, 66(2), 136-144 (1997)

Nitric oxide induces epidermal stem cell de-adhesion by targeting integrin beta1 and Talin via the cGMP signalling pathway

Zhan R, et al.

Nitric Oxide, 78, 1-10 (2018)

Immune parameters in the common octopus (Octopus vulgaris Cuvier, 1797) naturally infected by the gastrointestinal protozoan parasite Aggregata octopiana

Castellanos-Martinez S and Gestal C

Aquaculture (Amsterdam, Netherlands), 497, 487-493 (2018)

Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages.

Jonna Idh et al.

PloS one, 12(7), e0181221-e0181221 (2017-07-14)

Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical

NG-methyl-L-arginine functions as an alternate substrate and mechanism-based inhibitor of nitric oxide synthase

Olken NM and Marletta MA

Biochemistry, 32(37), 9677-9685 (1993)

모든 관련된 서류 보기

문서

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

N^G-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

SMILES string

InChI

assay

form

solubility

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

관련 참고 논문

관련 참고 프로토콜

문서

관련 콘텐츠

기술 서비스

NG-Methyl-L-arginine acetate salt

≥98% (TLC), powder, nitric oxide synthase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

InChI key

SMILES string

InChI

assay

form

solubility

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Features and Benefits

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

관련 참고 논문

관련 참고 프로토콜

문서

관련 콘텐츠

기술 서비스

N^G-Methyl-L-arginine acetate salt