M7397
L-(−)-Malic acid
suitable for cell culture, BioReagent, suitable for insect cell culture
동의어(들):
(S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
HO2CCH2CH(OH)CO2H
CAS 번호:
Molecular Weight:
134.09
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
EC Number:
202-601-5
Beilstein/REAXYS Number:
1723541
MDL number:
Assay:
≥95% (titration)
Form:
powder
biological source
microbial
product line
BioReagent
assay
≥95% (titration)
form
powder
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
mp
101-103 °C (lit.)
solubility
water: 100 mg/mL, clear to slightly hazy, colorless
Quality Level
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General description
Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks, jams, fruit and vegetable juices.
Application
Malic acid has been used:
- to induce basal respiration in mitochondrial cell culture
- to measure the mitochondrial ETC (electron transport chain) activity
- as a component of mitochondrial substrate stock
Biochem/physiol Actions
Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
저장 등급
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Biotechnology, 238-238 (1990)
Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus
Doherty E, et al.
Antioxidants & Redox Signaling, 21(1), 56-65 (2014)
Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system
Sauerbeck A, et al.
Journal of Neuroscience Methods, 198(1), 36-43 (2011)
Continuous production of L-malic acid by immobilized Brevibacterium ammoniagenes cells
Yamamoto K, et al.
Europ. J. Appl. Microbiol. Biotechnol., 3(3), 169-183 (1976)
Invertebrate Tissue Culture, 11-11 (2012)
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