M9292
Memantine hydrochloride
≥98% (GC), powder, NMDA glutamate receptor antagonist
동의어(들):
3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.13,7]decan-1-amine hydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C12H21N · HCl
CAS 번호:
Molecular Weight:
215.76
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
255-219-6
MDL number:
제품 이름
Memantine hydrochloride, ≥98% (GC)
Quality Level
InChI key
LDDHMLJTFXJGPI-VXMZOEJHSA-N
InChI
1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
SMILES string
Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2
assay
≥98% (GC)
form
powder
originator
Forest Labs
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)
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관련 카테고리
Application
Memantine hydrochloride has been used:
- as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity
- to intraperitoneally inject experimental animal to study its effect on traumatic injury
- as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration
Biochem/physiol Actions
Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.
Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Anton N Shuvaev et al.
International journal of molecular sciences, 22(15) (2021-08-08)
Spinocerebellar ataxias are a family of fatal inherited diseases affecting the brain. Although specific mutated proteins are different, they may have a common pathogenetic mechanism, such as insufficient glutamate clearance. This function fails in reactive glia, leading to excitotoxicity and
M Weller et al.
Brain research, 613(1), 143-148 (1993-06-04)
Effects of amantadine and memantine on NMDA receptor-mediated glutamate toxicity were studied in cultured cerebellar, cortical and mesencephalic neurons. Both drugs protected cerebellar and cortical neurons against glutamate toxicity, memantine being consistently more effective than amantadine but less effective than
C G Parsons et al.
Neuropharmacology, 32(12), 1337-1350 (1993-12-01)
Memantine (1-amino-3,5-dimethyladamantan) was tested as an antagonist of N-methyl-D-aspartate (NMDA) receptors on cultured superior collicular and hippocampal neurones using the patch clamp technique and its actions were compared to those of Mg2+ ions, ketamine, dextrorphan, dextromethorphan, phencyclidine and dizocilpine (MK-801).
Targeting different pathophysiological events after traumatic brain injury in mice: Role of melatonin and memantine
Kelestemur T, et al.
Neuroscience Letters, 612(1), 92-97 (2016)
Anton N Shuvaev et al.
Brain sciences, 12(4) (2022-04-22)
Memantine is an FDA approved drug for the treatment of Alzheimer's disease. It reduces neurodegeneration in the hippocampus and cerebral cortex through the inhibition of extrasynaptic NMDA receptors in patients and mouse models. Potentially, it could prevent neurodegeneration in other
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Product Information Sheet
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