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N0636

Nicotinamide

Name: Nicotinamide
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture

동의어(들):

Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B₃, Vitamin PP

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보기 변경

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₆H₆N₂O

CAS 번호:

98-92-0

Molecular Weight:

122.12

UNSPSC Code:

12352205

NACRES:

NA.75

PubChem Substance ID:

24897434

EC Number:

202-713-4

Beilstein/REAXYS Number:

383619

MDL number:

MFCD00006395

기술 서비스

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도움 문의

속성

biological source

synthetic (organic)

product line

BioReagent

assay

≥98% (HPLC)

form

powder

mol wt

M_w 122.12 g/mol

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

color

white

mp

128-131 °C (lit.)

solubility

water: soluble 50 mg/mL, clear, colorless

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

human ... PARP1(142), SIRT2(22933)

설명

General description

Nicotinamide (NAM) belongs to vitamin B family and is the amide form of vitamin B3. NAM is present in food and is a constituent of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Tryptophan is the precursor for NAM synthesis in liver. NAM controls cell metabolism, redox reactions, mitochondrial functionsand energy generation. It promotes natural killer cells proliferation and survival. NAM confers neuroprotection and promotes neuronal maturation. It has the ability to cross the blood-brain barrier and may provide protection in ischaemic stroke and traumatic brain injury. NAM may elicit therapeutic benefits in Alzheimer′s, Parkinson′s, and Huntington′s diseases.

Application

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells, esophageal squamous cell carcinomas(ESCC), pancreatic cancer organoids and pancreatic progenitor induction.