N193
1-Naphthylacetyl spermine trihydrochloride
≥95% (HPLC), Ca2+ permeable AMPA receptor channel blocker, powder
동의어(들):
NASPM trihydrochloride
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C22H34N4O · 3HCl
CAS 번호:
Molecular Weight:
479.91
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
1-Naphthylacetyl spermine trihydrochloride,
SMILES string
Cl.Cl.Cl.NCCCNCCCCNCCCNC(=O)Cc1cccc2ccccc12
InChI
1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
InChI key
JNEOJAUJWOPWJS-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
white
solubility
H2O: ≥20 mg/mL
Quality Level
관련 카테고리
Application
1-Naphthylacetyl spermine trihydrochloride has been used for the inhibition of calcium-permeable AMPAR (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor). It has also been used to study the involvement of AMPAR in biphasic activation of stress-activated protein kinase/extracellular signal-regulated kinase-1.
Biochem/physiol Actions
Blocks Ca2+ permeable AMPA receptor channels.
Other Notes
Synthetic analog of Joro spider toxin.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
K Oguro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(21), 9218-9227 (1999-10-26)
Considerable evidence suggests that Ca(2+)-permeable AMPA receptors are critical mediators of the delayed, selective neuronal death associated with transient global ischemia and sustained seizures. Global ischemia suppresses mRNA and protein expression of the glutamate receptor subunit GluR2 and increases AMPA
Drosophila motor neuron boutons remodel through membrane blebbing coupled with muscle contraction.
Fernandes, et al.
Nature Communications, 14, 3352-3352 (2023)
Biphasic activation of apoptosis signal-regulating kinase 1-stress-activated protein kinase 1-c-Jun N-terminal protein kinase pathway is selectively mediated by Ca2+-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors involving oxidative stress following brain ischemia in rat hippocampus
Zhang Q, et al
Neuroscience Letters, 337(1), 51-55 (2003)
Cornelia Strobel et al.
The Journal of physiology, 595(16), 5653-5669 (2017-06-09)
Dendritic and spine calcium imaging in combination with electrophysiology in acute slices revealed that in medial intercalated cells of the amygdala: Action potentials back-propagate into the dendritic tree, but due to the presence of voltage-dependent potassium channels, probably Kv4.2 channels
Blocking effect of 1-naphthyl acetyl spermine on Ca2+--p-ermeable AMPA receptors in cultured rat hippocampal neurons.
Koiki, M., et al.
Journal of Neuroscience Research, 29, 27-36 (1997)
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