N4142
Anti-Neurofilament 200 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
동의어(들):
NF200 Antibody - Anti-Neurofilament 200 antibody produced in rabbit, Nf200 Antibody, AntiNeurofilament heavy chain
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IHC (p), WB
Citations:
442
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 200 kDa
species reactivity
bovine, wide range
packaging
antibody small pack of 25 μL
enhanced validation
independent ( Antibodies)
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:80 using animal cerebellum sections, microarray: suitable, western blot: suitable
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NEFH(4744)
mouse ... Nefh(380684)
rat ... Nefh(24587)
General description
Neurofilament 200, also known as neurofilament heavy polypeptide (NEFH), is encoded by the gene mapped to human chromosome 22q12.2. The encoded protein has a molecular mass of 200kDa and belongs to the group of type IV intermediate filaments which are key constituents of the neuronal cytoskeleton. NEFH contains C-terminal motifs involved in the formation of sidearm projections which cross-link the neurofilaments.
Immunogen
Neurofilament 200 from bovine spinal cord.
Application
Anti-neurofilament 200 antibody produced in rabbit has been used for immunolabeling.
Anti-neurofilament 200 antibody produced in rabbit has been used:
Anti-neurofilament 200 antibody produced in rabbit has been used:
- for detection of neurofilaments using immunohistological staining
- in human astrocytoma cell line
- in post-mortem brain sections
- in human cremaster muscles
- for detection of neurofilaments by immunofluorescence staining in lumbar spinal cord sections of mice
Biochem/physiol Actions
Neurofilament 200 plays a vital role in cytoarchitecture organization. Downregulated expression of the gene has been observed in schizophrenia patients. Loss of gene expression is associated with the development of prostate carcinoma. Mutation in the gene leads to sporadic amyotrophic lateral sclerosis (ALS).
Neurofilament 200 assembly during development is critical for normal functioning of neuronal cells. Mutations in gene encoding neurofilaments is associated with neurological disorder called the Charcot–Marie–Tooth.
Neurofilament 200 assembly during development is critical for normal functioning of neuronal cells. Mutations in gene encoding neurofilaments is associated with neurological disorder called the Charcot–Marie–Tooth.
Shows a wide species cross-reactivity. Reacts with neurofilaments in the central and peripheral nervous system and localizes the neurofilament polypeptide.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at -20°C. For continuous use, the product may be stored at 2-8°C for up to one month. For extended storage, solution may be frozen in working aliquots at –20°C. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
저장 등급
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Hydrogen Peroxide-Induced Neurotoxicity in Cultured Cortical Cells Grown in SerumFree
and Serum-Containing Media
and Serum-Containing Media
Ricart KC and Fiszman ML.
Neurochemical Research, 26, 801-808 (2001)
In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration
Iordanova B and Ahrens ET.
Neuroimage, 59, 1004-1012 (2012)
Control of neurulation by the nucleosome assembly protein-1-like 2.
Rogner UC, et al.
Nature Genetics, 25, 431-435 (2000)
Peripherin-mediated death of motor neurons rescued by overexpression of neurofilament NF-H proteins.
Beaulieu JM and Julien JP
Journal of Neurochemistry, 85(1), 248-256 (2003)
Victor Vendrell et al.
Development (Cambridge, England), 142(16), 2792-2800 (2015-07-15)
Transcriptional regulatory networks are essential during the formation and differentiation of organs. The transcription factor N-myc is required for proper morphogenesis of the cochlea and to control correct patterning of the organ of Corti. We show here that the Otx2
관련 콘텐츠
Instructions
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.