N5389
Anti-Neurofilament H (200 kDa) Antibody
mouse monoclonal, NE14
동의어(들):
NF200 Antibody - Monoclonal Anti-Neurofilament 200 antibody produced in mouse, Neurofilament Antibody, Nf200 Antibody, Monoclonal Anti-Neurofilament heavy chain
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Conjugate:
unconjugated
Clone:
NE14, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (frozen sections)
microarray
western blot
immunohistochemistry (frozen sections)
microarray
western blot
Species reactivity:
pig, mouse, chicken, bovine, guinea pig, rabbit, rat, human
Citations:
84
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable
Uniprot accession no.:
제품 이름
Monoclonal Anti-Neurofilament 200 antibody produced in mouse, clone NE14, ascites fluid
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
NE14, monoclonal
mol wt
antigen apparent mol wt 200 kDa
contains
15 mM sodium azide as preservative
species reactivity
pig, mouse, chicken, bovine, guinea pig, rabbit, rat, human
enhanced validation
independent ( Antibodies)
Learn more about Antibody Enhanced Validation
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: suitable
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NEFH(4744)
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Immunofluorescence (1 paper)
Immunohistochemistry (1 paper)
Monoclonal Anti-Neurofilament 200 antibody produced in mouse has been used in
- immunohistochemistry
- immunolabeling
- immunofluorescence
Biochem/physiol Actions
Neurofilament heavy chain (NEFH) gene was recently identified to cause autosomal dominant axonal Charcot-Marie-Tooth disease (CMT2cc). This gene plays a role in the pathogenesis of sporadic amyotrophic lateral sclerosis (ALS). The phosphorylation of neurofilament polypeptides has been suggested to modulate their function by influencing the interaction between neurofilament and cytoplasmic organelles.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Neurofilament 200 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The neurofilaments are one of the five major groups of intermediate filaments (IFs) and are found predominantly in cells or tissues of neuronal origin. They are composed of three major proteins of apparent molecular weights 68 kD, 160 kD, and 200 kD and are named as NEFL (light), NEFM (medium) and NEFH (heavy) respectively. Neurofilament proteins are synthesized in the neuronal perikarya, assembled to form filaments and then slowly transported within the axons towards the synaptic terminals.
Immunogen
pig spinal cord.
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저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Neurofilament proteins are synthesized in nerve endings from squid brain
Crispino M, et al.
Journal of Neurochemistry, 61(3), 1144-1146 (1993)
Shaun M Logan et al.
Neuroscience letters, 545, 69-74 (2013-04-30)
Recent studies have shown that ephrin-B2 on sensory afferent fibers from the dorsal root ganglia (DRG) controls transmission of pain sensation to the spinal cord. We examined ephrin-B2 expression in mouse DRG and spinal cord using an ephrin-B2/ß-galactosidase chimeric allele.
Cell cycle kinetics and immunohistochemical characterization of dissociated fetal neocortical cultures: evidence that differentiated neurons have mitotic capacity
Jacobs JS and Miller MW
Dev. Brain Res., 122(1), 67-80 (2000)
Yuhki Saito et al.
eLife, 5 (2016-05-26)
The neuron specific RNA-binding proteins NOVA1 and NOVA2 are highly homologous alternative splicing regulators. NOVA proteins regulate at least 700 alternative splicing events in vivo, yet relatively little is known about the biologic consequences of NOVA action and in particular
Victoria A Baronas et al.
Nature communications, 9(1), 4417-4417 (2018-10-26)
Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored multi-protein complexes containing Kv1.2 using mass spectrometry followed by screening for effects on Kv1.2. We report that Slc7a5, a
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Datasheet
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