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Merck

N6505

β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt hydrate

≥95% (HPLC)

동의어(들):

β-NADPH, 2′-NADPH hydrate, Coenzyme II reduced tetrasodium salt, Dihydronicotinamide adenine dinucleotide phosphate tetrasodium salt, NADPH Na4, TPNH2 Na4, Triphosphopyridine nucleotide reduced tetrasodium salt

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크기 선택


제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C21H26N7Na4O17P3 · xH2O
CAS 번호:
Molecular Weight:
833.35 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Form:
powder
Assay:
≥95% (HPLC), ≥95% (spectrophotometric assay)
Solubility:
10 mM NaOH: soluble-50 mg/mL, clear, faintly to light yellow
Biological source:
chicken liver
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InChI

1S/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11+,13-,14+,15-,16+,20-,21+;;;;/m0..../s1

SMILES string

[Na+].[Na+].[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](OP([O-])([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O

InChI key

WYWWVJHQDVCHKF-MPUNMZHWSA-J

biological source

chicken liver

assay

≥95% (HPLC), ≥95% (spectrophotometric assay)

form

powder

solubility

10 mM NaOH: soluble-50 mg/mL, clear, faintly to light yellow

storage temp.

−20°C

Quality Level

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Application

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Biochem/physiol Actions

NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.

Preparation Note

Enzymatically reduced.

Other Notes

Packaged based on solid weight.

저장 등급

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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문서 라이브러리 방문

Carlos Blanco-Centurion et al.
The European journal of neuroscience, 19(10), 2741-2752 (2004-05-19)
The hypocretin neurons have been implicated in regulating sleep-wake states as they are lost in patients with the sleep disorder narcolepsy. Hypocretin (HCRT) neurons are located only in the perifornical region of the posterior hypothalamus and heavily innervate pontine brainstem
K A Vonnahme et al.
Journal of dairy science, 94(6), 2850-2858 (2011-05-25)
Objectives were to determine the effects of maternal dietary supranutritional Se and nutritional plane during gestation on capillary surface density, capillary area density, and angiogenic factor expression in the developing mammary gland of primiparous ewes. Selenium treatments were initiated at
Elodie Saudrais et al.
American journal of physiology. Cell physiology, 315(4), C445-C456 (2018-06-28)
Hydrogen peroxide, released at low physiological concentration, is involved in different cell signaling pathways during brain development. When released at supraphysiological concentrations in brain fluids following an inflammatory, hypoxic, or toxic stress, it can initiate lipid peroxidation, protein, and nucleic
Helia Tenza-Ferrer et al.
Frontiers in cellular neuroscience, 13, 306-306 (2019-07-30)
The incoming signals from injured sensory neurons upon peripheral inflammation are processed in the dorsal horn of spinal cord, where glial cells accumulate and play a critical role in initiating allodynia (increased pain in response to light-touch). However, how painful
Christine J Weydert et al.
Nature protocols, 5(1), 51-66 (2010-01-09)
Cells contain a large number of antioxidants to prevent or repair the damage caused by reactive oxygen species, as well as to regulate redox-sensitive signaling pathways. General protocols are described to measure the antioxidant enzyme activity of superoxide dismutase (SOD)

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