N6660

β-Nicotinamide adenine dinucleotide, reduced disodium salt

Name: β-Nicotinamide adenine dinucleotide, reduced disodium salt
Brand: SIGMA

~98%, pkg of 0.2 mg (per vial)

동의어(들):

β-DPNH, β-NADH, Coenzyme I reduced disodium salt, Diphosphopyridine nucleotide reduced disodium salt

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₁H₂₇N₇Na₂O₁₄P₂

CAS 번호:

606-68-8

Molecular Weight:

709.40

UNSPSC Code:

41106305

NACRES:

NA.51

PubChem Substance ID:

24897788

EC Number:

210-123-3

Beilstein/REAXYS Number:

5230241

MDL number:

MFCD00036200

Form:

powder

Assay:

~98%

주요 문서

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InChI key

QRGNQKGQENGQSE-QUWMEQBESA-L

InChI

1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11+,13-,14+,15-,16+,20-,21+;;/m0../s1

SMILES string

[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O

assay

~98%

form

powder

packaging

pkg of 0.2 mg (per vial)

Quality Level

200

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General description

β-Nicotinamide adenine dinucleotide (β-NAD) regulates energy metabolism and immunity. It is a cofactor for mitochondrial deacetylase sirtuin-3 enzyme and modulates inflammasome assembly. β-NAD supresses interleukin-1β levels in monocytic cells in inflammatory syndromes. β-NAD released by neurosecretory cells is a potential neurotransmitter. β-NAD is a vascular mediator in lung endothelial cells and may play a protective role against cytokine mediated inflammation.

Application

β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).

β-Nicotinamide adenine dinucleotide, reduced disodium salt has been used:

for the standard curve generation in neurotoxity assay of cortical neurons
in triosephosphate isomerase assay in jurkat JE6-1 cells
in lactate dehydrogenase assay

Biochem/physiol Actions

Electron donor

Preparation Note

Solutions should be prepared fresh and used promptly.

Other Notes

Packaged based on NADH content as determined by UV-Vis.

This is the common form of NADH; do not confuse with α-NADH.

저장 등급

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

13C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro

Cavallari E, et al.

Chemistry?A European Journal , 23(5), 1200-1204 (2017)

beta-Nicotinamide Adenine Dinucleotide (beta-NAD) Inhibits ATP-Dependent IL-1beta Release from Human Monocytic Cells

Hiller SD, et al.

International Journal of Molecular Sciences, 19(4), 1126-1126 (2018)

beta-Nicotinamide adenine dinucleotide attenuates lipopolysaccharide-induced inflammatory effects in a murine model of acute lung injury

Umapathy N, et al.

Experimental Lung Research, 38(5), 223-232 (2012)

beta-Nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons

Hwang SJ, et al.

Gastroenterology, 140(2), 608-617 (2011)

Deficiency of ATP13A2 leads to lysosomal dysfunction, alpha-synuclein accumulation, and neurotoxicity

Usenovic M, et al.

The Journal of Neuroscience, 32(12), 4240-4246 (2012)

모든 관련된 서류 보기

β-Nicotinamide adenine dinucleotide, reduced disodium salt

~98%, pkg of 0.2 mg (per vial)

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

InChI key

InChI

SMILES string

assay

form

packaging

Quality Level

설명

General description

Application

Biochem/physiol Actions

Preparation Note

Other Notes

안전성 정보

저장 등급

wgk

ppe

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

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