N6785
β-Nicotinamide adenine dinucleotide, reduced disodium salt
~98%, pkg of 10 mg (per vial)
동의어(들):
β-DPNH, β-NADH, Coenzyme I reduced disodium salt, Diphosphopyridine nucleotide reduced disodium salt
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C21H27N7Na2O14P2
CAS 번호:
Molecular Weight:
709.40
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
210-123-3
Beilstein/REAXYS Number:
5230241
MDL number:
Form:
powder
Assay:
~98%
Solubility:
10 mM NaOH: soluble-1 mg/mL, clear, colorless
InChI key
QRGNQKGQENGQSE-QUWMEQBESA-L
InChI
1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11+,13-,14+,15-,16+,20-,21+;;/m0../s1
SMILES string
[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O
assay
~98%
form
powder
packaging
pkg of 10 mg (per vial)
solubility
10 mM NaOH: soluble-1 mg/mL, clear, colorless
Quality Level
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Application
β-Nicotinamide adenine dinucleotide (NAD+) and β-Nicotinamide adenine dinucleotide, reduced (NADH) comprise a coenzyme redox pair (NAD+:NADH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. In addition to its redox function, NAD+/NADH is a donor of ADP-ribose units in ADP-ribosylaton (ADP-ribosyltransferases; poly(ADP-ribose) polymerases ) reactions and a precursor of cyclic ADP-ribose (ADP-ribosyl cyclases).
Biochem/physiol Actions
Electron donor
Preparation Note
Solutions should be prepared fresh and used promptly.
Other Notes
Packaged based on NADH content as determined by UV-Vis.
This is the common form of NADH; do not confuse with α-NADH.
Arvind Venkat Namuduri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2269-2286 (2020-01-08)
SUMOylation is a dynamic, reversible, enzymatic drug-targetable post-translational modification (PTM) reaction where the Small Ubiquitin-like Modifier (SUMO) moieties are attached to proteins. This reaction regulates various biological functions like cell growth, differentiation, and it is crucial for maintaining organ homeostasis.
"Clocks" in the NAD World: NAD as a metabolic oscillator for the regulation of metabolism and aging.
Shin-Ichiro Imai
Biochimica et biophysica acta, 1804(8), 1584-1590 (2009-11-10)
SIR2 (silent information regulator 2) proteins, now called "sirtuins," are an evolutionarily conserved family of NAD-dependent protein deacetylases/ADP-ribosyltransferases. Sirtuins have recently attracted major attention in the field of aging research, and it has been demonstrated that SIR2 and its orthologs
Richard P Ebstein et al.
FEBS letters, 585(11), 1529-1536 (2011-05-12)
Increasing evidence suggests that the nonapeptide, oxytocin (OT), helps shape social and affiliative behaviors not only in lower mammals but also in humans. Recently, an essential mediator of brain OT release has been discovered, ADP-ribosyl cyclase and/or CD38. We have
Weihai Ying
Frontiers in bioscience : a journal and virtual library, 11, 3129-3148 (2006-05-25)
Increasing evidence has indicated that NAD+ and NADH play critical roles not only in energy metabolism, but also in cell death and various cellular functions including regulation of calcium homeostasis and gene expression. It has also been indicated that NAD+
Xiaoling Li et al.
International journal of biological sciences, 7(5), 575-587 (2011-05-27)
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link
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