O104

Omeprazole

Name: Omeprazole
Brand: SIGMA

≥98% (HPLC), solid, gastric secretion inhibitor

동의어(들):

5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, Antra, Losec

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₁₇H₁₉N₃O₃S

CAS 번호:

73590-58-6

Molecular Weight:

345.42

UNSPSC Code:

12352200

PubChem Substance ID:

24897870

NACRES:

NA.77

MDL number:

MFCD00083192

Form:

solid

Quality level:

100

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제품 이름

Omeprazole, solid

SMILES string

COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C

InChI

1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

InChI key

SUBDBMMJDZJVOS-UHFFFAOYSA-N

form

solid

color

white

solubility

H₂O: 0.5 mg/mL
DMSO: >19 mg/mL
ethanol: 4.5 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ABCB1(5243), ATP4A(495), ATP4B(496), CYP1A2(1544)

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Application

Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands.

Biochem/physiol Actions

Omeprazole binds covalently to proton pump (H⁺, K⁺-ATPase) and inhibits gastric secretion. It is useful in ameliorating the effects of peptic oesophagitis, duodenal and gastric ulcer. Omeprazole is preferred over antagonists of histamine H2-receptor and ranitidine for its higher efficiency. It is also useful in treating Zollinger-Ellison syndrome.

Disclaimer

Hygroscopic, photosensitive

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H317,H411

pcodes

P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1

저장 등급

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Profiling the hepatic effects of flutamide in rats: A microarray comparison with classical AhR ligands and atypical CYP1A inducers

Coe KJ, et al.

Drug Metabolism and Disposition (2006)

Omeprazole Inhibits Glioblastoma Cell Invasion and Tumor Growth.

Un-Ho Jin et al.

Cancers, 12(8) (2020-08-01)

Background: The aryl hydrocarbon receptor (AhR) is expressed in gliomas and the highest staining is observed in glioblastomas. A recent study showed that the AhR exhibited tumor suppressor-like activity in established and patient-derived glioblastoma cells and genomic analysis showed that

Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies.

S E Attwood et al.

Alimentary pharmacology & therapeutics, 41(11), 1162-1174 (2015-04-11)

Control of chronic gastro-oesophageal reflux disease may be achieved either by anti-reflux surgery (ARS) or by long-term medical therapy with proton pump inhibitors (PPIs). The primary efficacy results of the SOPRAN study, comparing long-term omeprazole use with open ARS, and

Omeprazole

Michelle I. Wilde and Donna Mc Tavish

Drugs, 48(1), 91-132 (1994)

Omeprazole

S. Holt and C. W. Howden

Drugs, 36(4), 385?393-385?393 (1991)

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문서

Discover Bioactive Small Molecules for ADME/Tox

Omeprazole

≥98% (HPLC), solid, gastric secretion inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI

InChI key

form

color

solubility

originator

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

Application

Biochem/physiol Actions

Disclaimer

Features and Benefits

General description

안전성 정보

pictograms

signalword

hcodes

pcodes

Hazard Classifications

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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