O2751
Sodium oxamate
≥98%
동의어(들):
Aminooxoacetic acid sodium salt, Oxalic acid monoamide sodium salt, Oxamic acid sodium salt
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
NH2COCOONa
CAS 번호:
Molecular Weight:
111.03
UNSPSC Code:
12352202
NACRES:
NA.77
PubChem Substance ID:
EC Number:
209-290-5
Beilstein/REAXYS Number:
6538153
MDL number:
InChI
1S/C2H3NO3.Na/c3-1(4)2(5)6;/h(H2,3,4)(H,5,6);/q;+1/p-1
InChI key
RQVZIJIQDCGIKI-UHFFFAOYSA-M
SMILES string
[Na+].NC(=O)C([O-])=O
biological source
synthetic (organic)
assay
≥98%
form
powder
mp
300 °C
solubility
water: 50 mg/mL, clear, colorless
Quality Level
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Application
Sodium oxamate has been used:
- as one of the variable in flow injection analysis
- in in vitro angiogenesis assay
- to confirm the stimulatory role of stearic acid on lactate dehydrogenase mediated lactate production
Biochem/physiol Actions
Sodium oxamate influences the fatty acid metabolism. It might be useful for the treatment of diabetes.
Structural analog of pyruvate, inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway. Binding studies with lactate dehydrogenase; Mechanism of inhibition of mitochondrial pyruvate metabolism
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Role of ATP during the initiation of microvascularization: acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate
Muller Werner EG, et al.
The Biochemical Journal, 475(20), 3255-3273 (2018)
Black Inventors: Crafting Over 200 Years of Success, 5(20), 13092-13092 (2012)
Huo-Lei Peng et al.
Photochemistry and photobiology, 93(5), 1193-1203 (2017-04-10)
Fluorescence of Reduced Nicotinamide Adenine Dinucleotide (NADH) is extensively employed in studies of oxidoreductases. A substantial amount of static and kinetic work has focused on the binding of pyruvate or substrate mimic oxamate to the binary complex of lactate dehydrogenase
Otic Antiinfectives-Advances in Research and Application, 56-56 (2013)
Joshua Marshall Thornburg et al.
Breast cancer research : BCR, 10(5), R84-R84 (2008-10-17)
Glycolysis is increased in breast adenocarcinoma cells relative to adjacent normal cells in order to produce the ATP and anabolic precursors required for survival, growth and invasion. Glycolysis also serves as a key source of the reduced form of cytoplasmic
문서
Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.
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