O4139

Orlistat

Name: Orlistat
Brand: SIGMA

≥98% (HPLC), solid, lipase inhibitor

동의어(들):

(−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₉H₅₃NO₅

CAS 번호:

96829-58-2

Molecular Weight:

495.73

UNSPSC Code:

41106300

PubChem Substance ID:

24724564

NACRES:

NA.77

MDL number:

MFCD05662360

Assay:

≥98%

Form:

solid

Quality level:

200

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제품 이름

Orlistat, ≥98%, solid

SMILES string

CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O

InChI key

AHLBNYSZXLDEJQ-FWEHEUNISA-N

InChI

1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1

biological source

synthetic (organic)

assay

≥98%

form

solid

color

white

mp

<50 °C

solubility

DMSO: 19 mg/mL

originator

Roche

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... LIPF(8513), PNLIP(5406)

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General description

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Application

Orlistat has been used as an inhibitor:

of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
of lipase in screening lipase inhibition by raspberry extract
in in vitro pancreatic lipase activity assay

Biochem/physiol Actions

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Solution is not completely clear, small particles may remain floating.

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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문서 라이브러리 방문

Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype.

Shiva Kant et al.

Biochimica et biophysica acta, 1840(1), 294-302 (2013-09-26)

Orlistat, a fatty acid synthase (FASN) inhibitor, has been demonstrated to inhibit tumor cell survival. However, the mechanism(s) of its tumor growth retarding action against malignancies of hematological origin remains unclear. It is also not understood if the antitumor action

Risk of colorectal cancer after initiation of orlistat: matched cohort study

Hong JL, et al.

BMJ (Clinical Research ed.), 347(12), f5039-f5039 (2013)

Inhibitory effect of raspberries on starch digestive enzyme and their antioxidant properties and phenolic composition

Zhang L, et al.

Food Chemistry, 119(2), 592-599 (2010)

Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial

Chanoine JP, et al.

JAMA : The Journal of the American Medical Association, 293(23), 2873-2883 (2005)

Orlistat-associated adverse effects and drug interactions: a critical review.

Theodosios D Filippatos et al.

Drug safety, 31(1), 53-65 (2007-12-22)

Orlistat, an anti-obesity drug, is a potent and specific inhibitor of intestinal lipases. In light of the recent US FDA approval of the over-the-counter sale of orlistat (60 mg three times daily), clinicians need to be aware that its use

모든 관련된 서류 보기

문서

지질 신호전달 연구를 위한 생체 활성 저분자

Fatty Acid Synthesis in Cancer Cells

Fatty acid synthesis supports cancer cell proliferation, essential for membrane generation, protein modification, and bioenergetics.

Discover Bioactive Small Molecules for Lipid Signaling Research

프로토콜

LPL Activity Assay Protocol

Lipoprotein lipase (LPL) hydrolyzes triglycerides associated with VLDL.

Orlistat

≥98% (HPLC), solid, lipase inhibitor

크기 선택

제품정보 (DICE 배송 시 비용 별도)

주요 문서

속성

제품 이름

SMILES string

InChI key

InChI

biological source

assay

form

color

mp

solubility

originator

storage temp.

Quality Level

Gene Information

관련 카테고리

설명

General description

Application

Biochem/physiol Actions

Features and Benefits

Other Notes

안전성 정보

저장 등급

wgk

flash_point_f

flash_point_c

ppe

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