P0543
5-Pregnen-3β-ol-20-one-16α-carbonitrile
synthetic (organic), ≥97%, glucocorticoid receptor antagonist, powder, crystals or chunks
동의어(들):
Pregnenolone-16α-carbonitrile
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C22H31NO2
CAS 번호:
Molecular Weight:
341.49
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
제품 이름
5-Pregnen-3β-ol-20-one-16α-carbonitrile, ≥97%
SMILES string
C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI
1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
biological source
synthetic (organic)
sterility
non-sterile
assay
≥97%
form
powder, crystals or chunks
technique(s)
cell culture | mammalian: suitable
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
shipped in
ambient
storage temp.
2-8°C
Quality Level
관련 카테고리
Application
5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:
- in the induction of cytochrome P450
- as pregnane X receptor (PXR) activator in human liver cell lines.
Biochem/physiol Actions
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.
저장 등급
11 - Combustible Solids
wgk
WGK 3
flash_point_f
>199.9 °F - closed cup
flash_point_c
> 93.3 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
Katsuhide Igarashi et al.
The Journal of toxicological sciences, 37(2), 373-380 (2012-04-03)
The human steroid and xenobiotic receptor (SXR), (also known as pregnane X receptor PXR, and NR1I2) is a low affinity sensor that responds to a variety of endobiotic, nutritional and xenobiotic ligands. SXR activates transcription of Cytochrome P450, family 3
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
Ihunnah CA, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1812(8), 956-963 (2011)
Bin Zhang et al.
Endocrinology, 151(12), 5721-5729 (2010-10-22)
The androgen-androgen receptor signaling pathway plays an important role in the pathogenesis of prostate cancer. Accordingly, androgen deprivation has been the most effective endocrine therapy for hormone-dependent prostate cancer. Here, we report a novel pregnane X receptor (PXR)-mediated and metabolism-based
Aik Jiang Lau et al.
The Journal of pharmacology and experimental therapeutics, 335(3), 771-780 (2010-08-27)
Ginkgo biloba extract activates pregnane X receptor (PXR), but how this occurs is not known. Therefore, we investigated the mechanism of PXR activation by the extract and the role of five individual terpene trilactones in the activation. In a cell-based
Nozomu Moriya et al.
Biological & pharmaceutical bulletin, 35(4), 473-480 (2012-04-03)
Infection-associated inflammation can alter the expression levels and functions of cytochrome P450s (CYPs). Cyp gene expression is regulated by the activation of several nuclear receptors, including pregnane X receptor (PXR), constitutive androstane receptor (CAR), and aryl hydrocarbon receptor (AhR). These
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