P0547
Pentamidine isethionate salt
NMDA glutamate receptor antagonist, powder
동의어(들):
1,5-Bis(p-amidinophenoxy)pentane bis(2-hydroxyethanesulfonate salt), 4,4′-(Pentamethylenedioxy)dibenzamidine bis(2-hydroxyethanesulfonate)
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
Linear Formula:
CH2[CH2CH2OC6H4C(=NH)NH2]2·2HOCH2CH2SO3H
CAS 번호:
Molecular Weight:
592.68
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
205-424-1
MDL number:
Form:
powder
Quality level:
제품 이름
Pentamidine isethionate salt, powder
InChI key
YBVNFKZSMZGRAD-UHFFFAOYSA-N
InChI
1S/C19H24N4O2.2C2H6O4S/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23;2*3-1-2-7(4,5)6/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23);2*3H,1-2H2,(H,4,5,6)
SMILES string
OCCS(O)(=O)=O.OCCS(O)(=O)=O.NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(N)=N)cc1
form
powder
mp
188-194 °C (lit.)
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
originator
Celgene
storage temp.
−20°C
Quality Level
Gene Information
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관련 카테고리
Application
Antimicrobial against Pneumocystis carinii.
Pentamidine isethionate salt has been used:
- as a positive control for anti-leishmanial, anti-plasmodial and cytotoxic assays
- as a prototypical compound to analyse the inhibitor effect on human ether-a-go-go-related gene (HERG) K+ channel trafficking
- as an anti-leishmanial agent in promastigotes
Biochem/physiol Actions
Neuroprotective; inhibits constitutive nitric oxide synthase in the brain; NMDA glutamate receptor antagonist.
Pentamidine isethionate is used as a second line drug for leishmaniasis.
Features and Benefits
This compound was developed by Celgene. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
저장 등급
11 - Combustible Solids
wgk
WGK 3
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The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(3), 970-975 (1992-03-01)
Acquired immunodeficiency syndrome (AIDS) is frequently associated with dementia. The wide spectrum of neurological abnormalities associated with this dementia may involve a neurotoxin that activates the NMDA subtype of glutamate receptor in neurons. We have found that the antimicrobial agent
Anti-leishmanial lindenane sesquiterpenes from Hedyosmum angustifolium
Acebey L, et al.
Planta Medica, 76(04), 365-368 (2010)
Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds
Himmel HM
Journal of Pharmacological and Toxicological Methods, 68(1), 97-111 (2013)
Deiziane V S Costa et al.
Frontiers in cellular and infection microbiology, 11, 739874-739874 (2021-09-28)
The involvement of the enteric nervous system, which is a source of S100B, in Clostridioides difficile (C. difficile) infection (CDI) is poorly understood although intestinal motility dysfunctions are known to occur following infection. Here, we investigated the role of S100B
Reduced Antimony Accumulation in ARM58-Overexpressing Leishmania infantum.
Schafer C, et al.
Antimicrobial Agents and Chemotherapy, 58(3), 1565-1574 (2014)
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