P1093
Monoclonal Anti-Paxillin antibody produced in mouse
clone PXC-10, ascites fluid
์กฐ์ง ๋ฐ ๊ณ์ฝ ๊ฐ๊ฒฉ์ ๋ณด๋ ค๋ฉด ๋ก๊ทธ์ธ๋ฅผ ํด๋ฆญํฉ๋๋ค.
ํฌ๊ธฐ ์ ํ
์ ํ์ ๋ณด (DICE ๋ฐฐ์ก ์ ๋น์ฉ ๋ณ๋)
Conjugate:
unconjugated
Clone:
PXC-10, monoclonal
Application:
ARR, ICC, WB
Citations:
11
๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์๊ธฐ์ ์๋น์ค
๋์์ด ํ์ํ์ ๊ฐ์? ์ ํฌ ์๋ จ๋ ๊ณผํ์ ํ์ด ๋์๋๋ฆฌ๊ฒ ์ต๋๋ค.
๋์ ๋ฌธ์biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
PXC-10, monoclonal
mol wt
antigen 68-40 kDa
contains
15 mM sodium azide
species reactivity
bovine, rat, human, chicken, hamster
technique(s)
immunocytochemistry: suitable, microarray: suitable, western blot: 1:500 using a cultured human cell line extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20ยฐC
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PXN(5829)
rat ... Pxn(360820)
General description
Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.
Immunogen
C-terminal part of recombinant chicken paxillin (amino acids 305-559)
Application
Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.
Biochem/physiol Actions
Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.
Recognizes an epitope located in the LIM1 domain of the paxillin molecule.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
์ ํฉํ ์ ํ์ ์ฐพ์ ์ ์์ผ์ ๊ฐ์? ย
๋น์ฌ์ ์ ํ ์ ํ๊ธฐ ๋๊ตฌ.์(๋ฅผ) ์๋ํด ๋ณด์ธ์.
์ ์ฅ ๋ฑ๊ธ
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
๊ฐ์ฅ ์ต์ ๋ฒ์ ์ค ํ๋๋ฅผ ์ ํํ์ธ์:
์ด ์ ํ์ ์ด๋ฏธ ๊ฐ์ง๊ณ ๊ณ์ญ๋๊น?
๋ฌธ์ ๋ผ์ด๋ธ๋ฌ๋ฆฌ์์ ์ต๊ทผ์ ๊ตฌ๋งคํ ์ ํ์ ๋ํ ๋ฌธ์๋ฅผ ์ฐพ์๋ณด์ธ์.
Paxillin: a crossroad in pathological cell migration
Lopez CAM, et al.
Journal of Hematology & Oncology, 10(1), 50-50 (2017)
Paxillin: a new vinculin-binding protein present in focal adhesions.
Turner CE, et al.
The Journal of cell biology, 111(3), 1059-1068 (1990)
Emmanuella Tsirimonaki et al.
Virus research, 115(2), 158-168 (2005-09-20)
Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus (GA). E5
Gokhan Bahcecioglu et al.
International journal of biological macromolecules, 122, 1152-1162 (2018-09-16)
In this study, porcine fibrochondrocyte-seeded agarose, methacrylated gelatin (GelMA), methacrylated hyaluronic acid (MeHA) and GelMA-MeHA blend hydrogels, and 3D printed PCL scaffolds were tested under dynamic compression for potential meniscal regeneration in vitro. Cell-carrying hydrogels produced higher levels of extracellular
Armen H Mekhdjian et al.
Molecular biology of the cell, 28(11), 1467-1488 (2017-04-07)
Metastasis requires tumor cells to navigate through a stiff stroma and squeeze through confined microenvironments. Whether tumors exploit unique biophysical properties to metastasize remains unclear. Data show that invading mammary tumor cells, when cultured in a stiffened three-dimensional extracellular matrix
์์ฌ์ ๊ณผํ์ํ์ ์๋ช ๊ณผํ, ์ฌ๋ฃ ๊ณผํ, ํํ ํฉ์ฑ, ํฌ๋ก๋งํ ๊ทธ๋ํผ, ๋ถ์ ๋ฐ ๊ธฐํ ๋ง์ ์์ญ์ ํฌํจํ ๋ชจ๋ ๊ณผํ ๋ถ์ผ์ ๊ฒฝํ์ด ์์ต๋๋ค..
๊ณ ๊ฐ์ง์ํ์ผ๋ก ์ฐ๋ฝ๋ฐ๋๋๋ค.