P215
PD 98,059
MAPKK inhibitor, solid
동의어(들):
2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one, PD98059
조직 및 계약 가격을 보려면 로그인를 클릭합니다.
크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C16H13NO3
CAS 번호:
Molecular Weight:
267.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
제품 이름
PD 98,059, solid
SMILES string
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
form
solid
color
yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Quality Level
Gene Information
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Application
PD 98,059 has been used:
- in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
- in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
- in culture medium for cell migration assay
Biochem/physiol Actions
PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Sold with permission of Warner Lambert Company.
저장 등급
11 - Combustible Solids
wgk
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Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Chen J
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Zeng C, et al.
Journal of Hypertension, 27(5), 1033-1033 (2009)
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