P2795
Phytosphingosine hydrochloride
동의어(들):
4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C18H39NO3 · HCl
CAS 번호:
Molecular Weight:
353.97
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
form
powder
Quality Level
greener alternative product score
old score: 19
new score: 9
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greener alternative product characteristics
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
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sustainability
Greener Alternative Product
greener alternative category
lipid type
sphingolipids
storage temp.
−20°C
SMILES string
Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
InChI
1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
InChI key
GDKAAHDFPOWGQE-RXQQAGQTSA-N
Biochem/physiol Actions
Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.
저장 등급
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Ineke Spruijt et al.
PloS one, 14(7), e0219252-e0219252 (2019-07-02)
To reach pre-elimination levels of tuberculosis (TB) incidence in the Netherlands, prevention of TB among immigrants through diagnosis and treatment of latent TB infection (LTBI) is needed. We studied the feasibility of a LTBI screening and treatment program among newly
Marie-Thérèse El-Daher et al.
The EMBO journal, 34(17), 2255-2271 (2015-07-15)
Cleavage of mutant huntingtin (HTT) is an essential process in Huntington's disease (HD), an inherited neurodegenerative disorder. Cleavage generates N-ter fragments that contain the polyQ stretch and whose nuclear toxicity is well established. However, the functional defects induced by cleavage
Hyeseung Lee et al.
Molecular microbiology, 84(1), 130-146 (2012-02-22)
This study shows the importance of PDK1, TOR and PKC signalling pathways to the basal tolerance of Cryptococcus neoformans towards fluconazole, the widely used drug for treatment of cryptococcosis. Mutations in genes integral to these pathway resulted in hypersensitivity to