P3075
Phenylarsine oxide
synthetic (organic), ≥97%, tyrosine phosphatase inhibitor, powder
동의어(들):
Arzene, Oxophenylarsine, PAO
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크기 선택
제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C6H5AsO
CAS 번호:
Molecular Weight:
168.02
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352119
EC Number:
211-275-3
MDL number:
Beilstein/REAXYS Number:
2935227
제품 이름
Phenylarsine oxide, ≥97%, powder
InChI key
BQVCCPGCDUSGOE-UHFFFAOYSA-N
InChI
1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
SMILES string
O=[As]c1ccccc1
biological source
synthetic (organic)
assay
≥97%
form
powder
color
white to off-white
mp
145-148 °C
solubility
DMSO: 50 mg/mL
Quality Level
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Application
Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).
Biochem/physiol Actions
Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.
Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
General description
Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
저장 등급
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
M Wachtel et al.
Journal of cell science, 112 ( Pt 23), 4347-4356 (1999-11-24)
Regulation of epithelial and endothelial permeability is essential for proper function of compartmentalized organisms, and tyrosine phosphorylation plays an important role in this process. We analyzed the impact of protein tyrosine phosphatase (PTP) inhibition on the structure of endothelial junctional
Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study
Singh N, et al.
Acta Tropica, 159, 20-28 (2016)
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats
Lu X, et al.
Experimental neurology, 178(2), 259-267 (2002)
Yao Xiao et al.
Nature plants, 6(5), 544-555 (2020-05-13)
The 3-phosphoinositide-dependent protein kinase 1 (PDK1) is a conserved master regulator of AGC kinases in eukaryotic organisms. pdk1 loss of function causes a lethal phenotype in animals and yeasts, but only mild phenotypic defects in Arabidopsis thaliana (Arabidopsis). The Arabidopsis genome
Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
Lenartowicz E, et al.
Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)
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